Methods of Subtyping CRC and their Association with Treatment of Colon Cancer Patients with Oxaliplatin

ABSTRACT

A gene expression signature identifies stage II colon cancer patients who will receive benefit from oxaliplatin. Oxaliplatin has been shown to lengthen the survival of colon cancer patients, when it is combined with 5-fluorouracil plus leucovorin (FULV) in NSABP clinical trial C-07. Gene expression signatures are used first to classify tumors with regard to their respective subtypes, enterocyte, TA, goblet, inflammatory and stem-like and detection of expression of the enterocyte subtype directs treatment of the patient with oxaliplatin.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims benefit of priority to U.S. provisional application No. 62/011,571 filed Jun. 12, 2014, the entire contents of winch are incorporated herein by reference for all purposes.

BACKGROUND

Clinical trials MOSAIC (Andre, Boni et al, 2009)¹ (Multicenter International Study of Oxaliplatin, Fluorouracil, and Leueovorin trial) and C-07(Kuebler, Wieand et al. 2007)² showed that oxaliplatin added to fluorouracil (FU) and leucovorin (LV) significantly improved disease free survival (DFS) and established oxaliplatin as part of the standard of care for the adjuvant treatment of early-stage colon cancer. In the C-07 trial, 2,409 patients diagnosed with stage II and III colon adenocarcinoma who had undergone potentially curative surgical resection with no evidence of residual malignant disease were randomly assigned to receive either FULV (FU 500 mg/m2 by intravenous [IV] bolus weekly for 6 weeks; leucovorin 500 mg/m2 IV weekly for 0 weeks of each 8-week cycle for three cycles) or FLOX (FULV plus oxaliplatin 85 mg/m2 IV on days 1, 15, and 29 of each cycle). Based on the 2011 analysis with median follow-up of 8 years, FLOX demonstrated superior DFS (HR; 0.82; P=002)(Kuebler, Wieand et at 2007)². Current NCCN guidelines recommend that all stage III patients, and high risk stage II patients be treated with oxaliplatin. High risk stage II includes patients with perforation, or obstruction or rumors with lymphovascular or perineural invasion, T4 lesions, less than 12 Lymph nodes examined, or grade 3-4 lesions. However, recent analysis of MOSAIC analysis found no statistically significant benefit for either all stage II or high risk stage II patients (Tournigand, Andre et al. 2012)³. The use of oxatiplatin in all early stage colon cancer patients remains controversial not only because it is uncertain which patients actually receive benefit but also because of the toxic side effects associated with oxaliplatin (Cersosimo 2005)⁴. Thus, stratifying patients with regard to their oxaliplatin benefit is of significant clinical interest.

Recently, several studies (De Sousa, Wang et al. 2013; Marisa, de Reynies et al. 2013; Sadanandam, Lyssiotis et al. 2013) have used unsupervised clustering methods to develop genomic signatures to classify colorectal cancer to different intrinsic subtypes and showed that each subtype has distinct molecular features, clinical significance and prognosis. These groups identified either 3 or 5 intrinsic subtypes with the CCS3, Stem-Like as the poorest prognostic group. The different number of clusters in these publications is not surprising given that different methods and different training, datasets were used. Sadanandam et al's (Sadonandam, Lyssiotis et at 2013)⁹ five subtypes were correlated, to gene expression patterns of the different cell types located within the normal colonic crypts. De Sousa et al also demonstrated that most of the published gene expression based prognostic assays identify essentially the same group of tumors (mostly stem-like or CCS3 subtypes) as those associated with high tisk of relapse. Given that it is now well established that breast cancer subtypes differ regarding their prognosis and their response to treatment, it was reasonable to hypothesize that the clinical behavior of the different colon subtypes may also differ with respect to prognosis and importantly with response to treatment. However, it was not possible to test treatment response in these published studies because the patient cohorts were treated with a variety of agents and were not part of a randomized clinical trial designed to test a particular agent. In contrast the gene expression data which was profiled on archived tumor blocks from NSABP clinical trial C-07 represented an ideal experimental cohort to test whether colon cancer subtypes could be used to predict oxidiplatin benefit. Before the publication of these colon cancer subtypes we had completed the gene expression profiling of 1846 patients from C-07 using our custom nCounter code set using nCounter assays from Nanostring Technologies.

SUMMARY

The initial study described here provides a gene expression signature which identifies stage II and III colon cancer patients who will receive benefit from oxaliplatin. Oxaliplatin has been shown to lengthen the survival of colon cancer patients, when it is combined with 5fluorouracil plus leucovorin (FULV) in NSABP clinical trial C-07. However, mounting evidence suggest that not all early stage colon cancer patients benefit from oxaliplatin treatment and the toxicities associated with oxaliplatin highlights the importance of identifying patients who will actually receive benefit from oxaliplatin treatment. We have used gene expression signatures to first classify tumors in C-07 with regard to their respective subtypes, enterocyte, TA, goblet, inflammatory and stem-like and shown that only the enterocyte subtype received benefit from oxaliplatin. Comparing the benefit in the enterocyte subtype to a second group consisting of all four other subtypes, (Goblet-like, Inflammatory, Stem-like and TA) as a non-benefit group, showed a significant treatment-group interaction (p=0.012). In a second step we showed that the stem-like subtype can be further sub-typed into patients who do and do not receive benefit from oxaliplatin. Identification of this sub-subtype which received benefit from oxaliplatin is also of clinical interest in that the stem-like subtype has a very poor prognosis.

We have profiled 296 genes in 1840 patients from NSABP clinical trial C-07 using a custom nCounter code set using the nCounter Assay system from Nanostring Technologies (Seattle Wash.). Genes selected for inclusion on our custom nCounter code set were a result of our own gene expression analysis of the C-07 discovery cohort or other published studies. Gene espression profiling was conducted on tumor blocks from patients with follow-up information and proper consent. Samples within C-07 were split into non-overlapping discovery (N=848) and validation cohorts (N=992). The current description involves only the use of the discovery cohon. Clinical data and nCounter data for the discovery dataset were merged and anonyinized by the honest broker at the University of Pittsburgh as defined by standard operations under IRB approval of the NSABP Biospecimen Bank and Biostatistics Center.

We have developed a predictive algorithm to classify tumors into oxaliplatin benefit or no benefit group using discovery cohort of 848 patients without access to the data from the remaining 992 patients (validation cohort). The nCounter genes used for this analysis are 72 genes included in both our custom nCounter code set (N=296) and in the intrinsic subtype signature described by Sadanandam et al. (Sadanandam, Lyssiotis et al. 2013)

The current disclosure can be described therefore as a method for treating colon cancer in a patient in need thereof said method comprising obtaining a tumor tissue sample from said patient determining a gene expression signature of said sample identifying a tumor tissue subtype from said gene expression signature; and administering oxaliplatin when the identified tumor tissue subtype is an oxaliplatin responsive subtype. As used herein subtype can refer to one of five colon cancer subtypes, enterocyte, TA, goblet, inflammatory and stem-like, and sub-subtype can refer to a division within one of the 5 subtypes that is more enterocyte-like or that is more responsive to oxaliplatin, for example, than other genes within the subtype.

The methods can be further described therefore as determining a gene expression signature by steps including contacting a genetic sample from the tumor tissue sample with a plurality of specific genetic sequence binding targets and measuring the amount of genetic material expressed by the minor tissue for a panel of selected genes, wherein the panel of genes are selected from those listed in Table 5. A gene binding target can be a polynucleotide, a protein, a peptide or a peptide nucleic acid, and as such can be synthesized based on a complementary sequence or on a synthetic molecule designed to specifically bind to the RNA. The sample or the target can be affixed to a solid surface such as a planar surface, contained in or affixed to a bead or contained in an oil droplet, for example, or in other forms known in the art such as but not limited to next-genetation sequencing technologies such as RNA-Seq or whole transcriptome sequencing.

In certain preferred embodiments the genetic sample comprises degraded or intact RNA and can be mRNA or total RNA or whole tissue lysates from selected genes from Table 5. In certain embodiments the panel of genes for determination of a gene signature are selected by a process that includes Weighted Gene Correlation Network Analysis (WGCNA), to identify members of oxaliplatin responsive gene modules.

Disclosed methods of treatment include administration of oxaliplatin is administered in combination with 5-fluorouracil plus leucovorin (FULV), and can include administration to a stage II or stage III colon cancer patient. The tumor sample can be subtype enterocyte or TA or a sub-subtype of enterocyte or TA. In certain embodiments cancer tumor sample is subtype stem-like or a sub-subtype of stem-like.

The disclosure can also be described in certain embodiments as method for treating colon cancer in as patient in need thereof said method comprising, obtaining a tumor tissue sample from said patient; isolating RNA from the tumor tissue sample; contacting the RNA sample with a plurality of sequence specific probes effective to determine levels of expression or a panel of selected genes in the tumor sample to obtain a gene signature identifying a colon cancer subtype or sub-subtype tumor subtype based on the gene signature; and administering oxaliplatin or causing oxaliplatin to be administered to said patient when the cancer subtype or sub-subtype is an oxaliplatin responsive subtype or sub-subtype. Gene specific probes can include complementary nucleic acid sequences or other probes that do not necessarily bind to a site within the gene such as those used for Next-generation sequencing technologies which quantitate RNA by sequencing RNA molecules directly, for example.

The method can include utilizing a panel of selected genes are selected from the genes listed in Table 5. The methods can further include administering oxaliplatin or causing oxaliplatin to be is administered in combination with 5-fluorouracil plus leucovorin (FULV) to a stage II or stage III colon cancer patient, were the patient's tumor tissue is determined to be subtype enterocyte or TA or a sub-subtype of enterocyte or TA, or subtype stem-like or a sub-subtype of stem-like.

BRIEF DESCRIPTION OF THE DRAWINGS

The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present inventions. The disclosure can be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.

FIG. 1 Design of Study for discovery and validation of a signature to identify patients who will benefit from oxaliplatin. In this description only the discovery cohort has been used for signature development.

FIG. 2 shows the steps that were taken to develop predicitive algorithm using nCounter data from the discovery cohort of C-07.

FIG. 3 Kaplan Meier Plots of each CRC subtype using our gene signature by CRC-SSP-72 according to treatment (FULV versus FOLFOX) using recurrence free survival (RFS) as the end point. Among identified CRC subtypes, only Enterocyte received significant benefit (HR=0.315, p=0.005).

FIG. 4 Kaplan Meier Plots of the Enterocyte subtype and of all of the other subtypes (Goblet-like, Inflammatory, Stem-like and TA) combined into one group (Others) There is significant treatment-group interaction (p=0.012)

FIG. 5 Reproducibility of a C07 sample (C-07-0286) measured by nCounter. This sample was tested using 100, 150, 200, and 250 ng of total RNA as input.

FIG. 6 Venn diagram of genes used for developing subtype classifiers.

DETAILED DESCRIPTION

The present invention provides methods for identifying tumors which are responsive to oxaliplatin in individuals. The methods involves the gene expression analysis of RNA isolated from tissue or other biological sources such as blood, urine o or feces using nCounter Assays from Nanostring Technologies Inc. or other gene exprression methodologies such as microarray, RNA-Seq, hybrid capture RNA sequencing or other state of the art RNA expression profiling methodologies, identifying the colon cancer intrinsic subtypes, identifying the subtypes that received benefit from oxaliplatin. As used herein isolated RNA is meant to convey any separation of RNA from its environment in a cell, including any fractionation, binding, filtration, degradation or even cell rupture such as a lysate.

Clinical samples and histological evaluation used in this description. Samples used in this disclosure were from NSABP clinical trial C-07. This trial enrolled patients between 02/2000 and 11/2002 to compare oxaliplatin and bolus 5-FU/LV to bolus 5FU/LV alone for resected stage II and III colon cancer². C-07 was approved by an Institutional Review Board and informed consent was obtained from each subject for biomedical research.

I. nCounter Assays used to Determine Gene Expression

The nCounter platform by Nanostring Technologies was used to profile gene expression in RNAs isolated from rumors collected in NSABP clinical trial C-07 which is an ideal platform for a clinical assay for chemically modified and degraded RNAs isolated from FFPE because it requires no enzymology, requires small amounts of total RNA, capture and detection probes target less than 100 bp sequence, and the process is largely automated requiring little hands on time.

The C-07 customized nCounter code set consisted of 296 genes plus 6 positive and 8 negative technical control genes. The 2% genes included in this nCounter code set were selected for the following reasons; the genes were prognostic or predictive for oxaliplatin benefit in the C-07 discovery cohort using whole genuine DASL arrays (WG_DASL) from Illumina Inc or were part of significant pathways identified in C07 DASL data analysis or were from the literature or other internal data.

We have profiled 296 genes in 1840 patients using the nCounter Assay system (Nanostring Technologies, Seattle Wash.). Clinical data and nCounter data for the discovery dataset were merged and anonymized by the honest broker at the University of Pittsburgh as defined by standard operations under IRB approval of NSABP Biospecimen Bank and Biostatistics Center. We have developed a predictive algorithm to classify tumors into oxaliplatin benefit or no benefit group using discovery cohort of 848 patients without access to the data from the remaining 992 patients (validation cohort).

II. Study Design

For C07, 2409 patients were enrolled in C-07 and all cases with tumor blocks, proper consent, clinical follow-up information and sufficient RNA yields were used in this study (N=1840). These cases were split into a discovery (N=848) and a validation (N=992) cohort (FIG. 1). The present signature was developed with the discovery cohort.

A. Intrinsic Subtype and Oxaliplatin Benefit:

The steps for signature development are summarized in FIG. 2.

With the goal of developing genomic predictive biomarker for oxaliplatin benefit, we first identified intrinsic subtypes and tested oxaliplatin benefit in each subtype. The disclosed methods focused on the CRC intrinsic subtypes identified by Sadanandam⁶, and the CCS intrinsic subtypes identified by De Sousa⁷. Since nCounter assay was designed before the publication of the above papers, only a small proportion of intrinsic genes were matched to genes included in the nCounter assay. For example, for the CRC study⁶, among 1262 non-specific filtered genes, only 72 exist in the nCounter code dataset, and among 786 identified intrinsic subtyping genes, only 56 exist in the nCounter code dataset. Our analysis indicated that subtype can be identified with a subset of 786 genes. Based on the 56 genes, using SSP method, specifically, we checked the Spearman correlation between each sample and the subtype centroid, and then assigned each sample to the subtype to which it was most correlated. This method correctly identified subtype in 79% of the samples.

To improve the robustness of subtype identification, we redeveloped centroid for each subtype based on the 72 genes that overlap between C-07 nCounter code dataset and the original CRC training dataset. We then applied SSP method to the C-07 training data i.e., we checked the Spearman correlation between each sample and the subtype centroid using the 72 genes (Table 1), then assigned each sample to the most correlated subtypes. We can correctly identify the subtype in 80% of the samples (Table 2). Clinical variables such as T stage, nodal status perforation and mutation status of BRAF, KRAS, NRAS and PIK3CA of each subtype are shown in Table 3.

TABLE 1 Centroid of CRC-SSP-72. Enterocyte Goblet.like Inflammatory Stem-like TA AKAP12 −0.1564 −0.3258 −1.00E−04 0.6652 −0.1946 ANKRD44 0.0701 −0.1685 0.2335 0.0874 −0.1798 BGN −0.2625 −0.3363 0.1203 0.684 −0.2285 BHLHE4I 0.1079 0.075 0.0015 0.2663 −0.3092 BMP7 −0.2046 −0.0645 −0.143 0.04 0.2408 C8orf84 −0.4073 0.5791 −0.0724 −0.1541 0.0682 CAB39L −0.0904 −0.2837 −0.4717 0.1316 0.4798 CDKN2B 0.6162 −0.4035 −0.0118 0.222 −0.2867 CKMT2 0.0206 −0.2473 −0.2254 −0.0649 0.3515 COL11AI −0.4436 −0.3797 0.189 0.7476 −0.1898 COMP −0.4057 −0.202 −0.1175 0.7747 −0.1101 CPE 0.091 0.1071 −0.4766 0.2741 0.0311 CSGALNACT1 −0.2585 −0.0478 −0.0254 0.2363 0.0324 CXCL10 −0.1897 −0.1776 0.7137 −0.0052 −0.302 CXCL11 −0.203 −0.115 0.6691 −0.0649 −0.2545 CXCL13 0.11 −0.2356 0.8126 −0.1015 −0.4541 CXCL2 −0.1416 0.0466 0.1917 −0.2284 0.0826 CXCL9 −0.2303 −0.2078 0.7334 −0.006 −0.2731 CYP1B1 −0.3509 −0.242 0.0875 0.8449 −0.3248 DAPK1 −0.2495 0.3342 0.3441 0.1757 −0.4336 DCBLD2 −0.2662 −0.1791 0.1036 0.335 −0.0522 DPEP1 −0.1993 0.0196 −0.4644 −0.0446 0.4881 EPB41L4B 0.1808 −0.0063 −0.2888 −0.3419 0.3594 ERAP2 −0.0712 0.0416 0.4002 −0.1821 −0.1445 F5 −0.2002 0.0195 0.2094 −0.0196 −0.03 FAP −0.2881 −0.2525 0.1586 0.6969 −0.301 FGL2 0.1732 −0.1883 0.3211 0.1058 −0.3093 FN1 −0.2859 −0.4114 0.1302 0.5476 −0.0764 FNDC1 −0.2566 −0.3827 −0.0213 0.8409 −0.2125 GBP1 −0.1684 −0.2325 0.6939 0.0308 −0.2952 GBP4 −0.1999 −0.1174 0.7101 −0.1899 −0.1937 GPX3 0.0253 −0.1816 −0.0432 0.4493 −0.203 GRM8 −0.0273 −0.1092 −0.3808 −0.2021 0.5153 GZMB −0.2513 −0.4275 0.3314 −0.167 0.2865 HGD 0.2535 0.3355 −0.0656 −0.3365 −0.0593 HOXA13 −0.0301 0.1091 −0.0917 −0.2152 0.1795 HSD17B2 0.6687 −0.0054 0.1407 −0.3991 −0.2153 ID4 −0.1789 0.0325 −0.2977 0.4248 0 IDO1 −0.2064 −0.1664 0.7754 −0.2062 −0.1969 IL8 −0.166 −0.0459 0.3226 0.0624 −0.156 INHBA −0.3224 −0.2377 0.1021 0.6646 −0.2233 MFAP5 1.00E−04 −0.3641 −0.1964 0.8067 −0.2264 MGP 0.0509 −0.4134 −0.1745 0.8961 −0.3097 MMP11 −0.1743 −0.2439 −0.1581 0.462 0.0318 MMP28 0.4253 0.2425 0.1082 −0.1931 −0.3441 NFIB 0.0535 −0.0317 −0.5168 0.0032 0.3672 OAS2 −0.1136 0.0199 0.4392 −0.0611 −0.2234 PAPPA −0.0641 −0.2033 0.0437 0.3593 −0.1342 PIGR 0.2984 0.2771 0.2527 −0.4536 −0.2038 PLA2G12B −0.0591 −0.2634 −0.3123 −0.1001 0.5015 POU2AF1 0.3543 0.2138 0.147 −0.1889 −0.3155 PRAP1 −0.0074 −0.2188 −0.4551 0.0767 0.4181 PROM2 0.2046 0.1593 −0.0655 −0.2981 0.0462 PSMB9 −0.1726 −0.0019 0.4983 −0.2105 −0.1072 PTPRC 0.0416 −0.252 0.5649 0.1694 −0.4187 ROBO1 −0.1221 −0.2991 0.0818 0.2661 −0.0014 SDC2 −0.0982 −0.2924 −0.0399 0.5358 −0.1257 SELL 0.0788 −0.1222 0.2456 0.0016 −0.1589 SERPINE1 −0.1613 −0.116 0.0757 0.3678 −0.1574 SFRP2 −0.2103 −0.5022 0.0497 1.0716 −0.3926 SGK2 0.2445 −0.2138 −0.4084 −0.2707 0.4818 SLC4A4 1.099 0.1349 0.0933 −0.461 −0.4826 SPARC −0.1227 −0.3431 0.0146 0.6662 −0.218 SPP1 −0.3134 −0.1681 0.4032 0.4321 −0.3238 SSPN −0.0575 −0.0801 −0.1318 0.5308 −0.206 STC1 −0.3185 −0.1163 0.2305 0.2822 −0.1135 TACSTD2 −0.0954 0.2113 −0.0379 0.109 −0.1196 TGFBR3 −0.1721 −0.0829 −0.016 0.04 0.1378 TM4SF1 −0.1527 −0.1754 −0.0883 0.0963 0.1938 TYMS −0.1895 0.1904 0.4728 −0.3805 −0.0701 VCAN −0.1637 −0.3038 −0.0031 0.7104 −0.2344 VNN1 0.0753 0.2341 0.4957 −0.2096 −0.4016

TABLE 2 Consistency between CRC-SSP-72 and original algorithm in identifying CRC subtypes. Truth Goblet- Inflam- Stem- Enterocyte like matory like TA Prediction Enterocyte 40 0 0 0 4 Goblet.like 5 42 2 0 3 Inflammatory 11 9 68 2 4 Stem-like 8 8 6 75 10 TA 0 4 2 0 84

TABLE 3 Patient characteristics by intrinsic subtype identified by CRC-SSP-72. Enterocyte Goblet-like Inflammatary Stem-like TA Gender F 43 (47.3%) 22 (34.9%)  89 (44.1%)  95 (39.7%)  79 (43.2%) M 48 (52.7%) 41 (65.1%) 113 (55.9%) 144 (60.3%) 104 (56.8%) Stage II 26 (28.6%) 20 (31.7%)  88 (43.6%)  57 (23.8%) 42 (23%)  III 65 (71.4%) 43 (68.3%) 114 (56.4%) 182 (76.2%) 141 (77%)   Grade Diff 80 (87.9%) 51 (81%)   126 (62.4%) 194 (81.2%) 168 (91.8%) undiff 11 (12.1%) 12 (19%)    76 (37.6%)  45 (18.8%) 15 (8.2%) TStage T12 15 (16.5%) 11 (17.5%) 17 (8.4%)  7 (2.9%)  28 (15.3%) T3 71 (78%)   46 (73%)   176 (87.1%) 213 (89.1%) 144 (78.7%) T4 5 (5.5%) 6 (9.5%)  9 (4.5%) 19 (7.9%) 11 (6%)   Perforation 0 89 (97.8%) 62 (98.4%) 196 (97%)   231 (96.7%) 179 (97.8%) 1 2 (2.2%) 1 (1.6%) 6 (3%)  8 (3.3%)  4 (2.2%) Nodes positive 0 26 (28.6%) 20 (31.7%)  88 (43.6%)  57 (23.8%) 42 (23%)  detected 1-3 43 (47.3%) 32 (50.8%)  78 (38.6%) 107 (44.8%) 108 (59%)   4+ 22 (24.2%) 11 (17.5%)  36 (17.8%)  75 (31.4%) 33 (18%)  MSI status MSS 77 (100%)  50 (87.7%) 131 (72.4%) 193 (94.1%) 162 (97.6%) MSI 0 (0%)    7 (12.3%)  50 (27.6%) 12 (5.9%)  4 (2.4%) BRAFmutated w 83 (91.2%) 48 (78.7%) 145 (72.9%) 205 (86.1%) 177 (96.7%) m 8 (8.8%) 13 (21.3%)  54 (27.1%)  33 (13.9%)  6 (3.3%) KRASmutated w 64 (71.9%) 26 (44.1%) 129 (66.8%) 126 (54.1%) 121 (66.9%) m 25 (28.1%) 33 (55.9%)  64 (33.2%) 107 (45.9%)  60 (33.1%) METmutated w 85 (96.6%) 56 (94.9%) 184 (95.3%) 227 (97.4%) 174 (96.1%) m 3 (3.4%) 3 (5.1%)  9 (4.7%)  6 (2.6%)  7 (3.9%) NRASmutated w 85 (96.6%) 56 (94.9%) 190 (99%)  226 (97%)   176 (97.2%) m 3 (3.4%) 3 (5.1%) 2 (1%) 7 (3%)   5 (2.8%) PIK3CAmutated w 74 (84.1%) 46 (76.7%) 142 (73.2%) 175 (74.8%) 158 (87.3%) m 14 (15.9%) 14 (23.3%)  52 (26.8%)  59 (25.2%)  23 (12.7%) RFI Status 0 59 (64.8%)  4 (74.6%) 173 (85.6%) 141 (59%)   132 (72.1%) 1 32 (35.2%) 16 (25.4%)  29 (14.4%) 98 (41%)   51 (27.9%) OS Status 0 54 (59.3%) 40 (63.5%) 156 (77.2%) 138 (57.7%) 121 (66.1%) 1 37 (40.7%) 23 (36.5%)  46 (22.8%) 101 (42.3%)  62 (33.9%)

As shown in FIG. 3, among identified CRC subtypes, only Enterocyte received significant benefit (HR=0.315, p=0.005). In combining all other four subtypes. Goblet-like, Inflammatory, Stem-like and TA as a non-benefit group, there is significant treatment-group interaction (p=0.012) (FIG. 4). However when stage II and III CRC patients were tested separately only stage III patients showed differential benefit from oxaliplatin when subtyped with our 72 gene signature (FIG. 5).

Similarly, we also identified CCS colon cancer subtypes which include CCS1, CCS2 and CCS3⁷. Consistent with other studies the CRC clustering and CCS clustering are correlated with each other, i.e., most CCS1 patients are TA or Enterocyte patients, most CCS2 patients are inflammatory and most CCS3 are stem-like patients. Since CCS did not separate Enterocyte which received significant benefit from oxaliplatin from other TA patients, we decided to use SSP-72 to identify CRC subtypes.

III. RNA Expression Profiling using nCounter Assay System

Gene expression profiling by nCounter Assay System. The nCounter platform was selected as the platform for a clinical assay for degraded RNAs isolated from FFPE because it requires no enzymology, requires only 100 to 300 ng of total RNA, capture and detection probes target less than 100 bp sequences, and the process is largely automated requiring little hands on time. The C-07 customized nCounter code set consisted of 296 genes plus 6 positive and 8 negative technical control genes. The 296 genes included in this nCounter code set were selected for the following reasons: the genes were prognostic or predictive for oxaliplatin benefit in the C07 discovery cohort using DASL data or were part of significant pathways identified in C07 DASL data analysis or were from the literature. nCounter assay data processing

QC of the nCounter assay data: Quality control of the data was performed using default flags in the NSolver software that is provided by the manufacturer:

-   -   1) Imaging flag—sample removed if less than ¾ of the expected         fields of view are captured by the camera (0.75*600=450 minimum         FOVs)     -   2) Binding Density—sample removed if the binding density falls         outside the range 0.05−2.25     -   3) Positive Control Flag—sample removed if the positive spikes         do not follow the expected linear trend (r̂2<0.95)     -   4) 0.5 fm Detection Flag—sample removed if the 0.5 fm positive         control is within two standard deviations of the negative         controls     -   5) Tech Normalization Flag—for the raw data,         median(sum(pos(controls))/sum(positive control); sample removed         if the technological normalization factor >3 or <0.3     -   6) Biological Normalization Flag—after adjusted by technical         normalization, median (geomean(pos(house-keeping         controls)/geomean(house-keeping control); sample removed if the         biological normalization factor <0.1 or >10. In this data,         KIAA1539, MADD, RAB1A, C17orf79, PDCD10, NFYC were selected as         house-keeping genes.     -   7) If repeated measurements for an individual both pass above         criteria, the lane with the lesser total counts will be removed

With the above criteria, 778 out of 848 samples (91.75%) pass QC and were used for signature development.

1. Nanostring Data Normalization

After preprocessing data, we normalized each tumor for technical variability with the stint of the positive controls inherent to nCounter assay and within sample reference normalized with the geometric mean of 6 internal reference genes (KIAA1539, MADD, RAB1A, C17orf79, PDCD10,NFYC).

2. Analytical Performance of mRNA Expression Profile by nCounter:

Dynamic range and limit of detection for the nCounter assay can be estimated from synthetic, spike-in controls included with every sample. Positive controls are spiked into the reaction at concentrations from 0.125-128 fM, representing a fold-change of 1024. Measurements of these controls are highly linear (median r²=0.99 across all discovery samples) in this range. Eight negative control probes, representing sequences not found in the human transcriptome, are also included in each reaction. The lowest positive control, 0.125 fm, represents approximately 0.2 copies per cell, and is detected at least 2 standard deviations above the mean of the negative controls. If r² for the positive spikes drops below 0.95 or the 0.125 fm spike is not detected 2 standard deviations above the mean of the negative controls, the reaction is considered failed and that sample is repeated or removed from further analysis.

We also tested 11 pairs of samples as duplicate. For these duplicate samples, we calculated the correlation coefficients for the gene expression, the minimum of correlation coefficient is 0.9912, and mean is 0.9925, standard deviation is 0.0021.

To address assay reproducibility and required amount of input RNA, we first performed several samples using 100, 150, 200, and 250 ng of total RNA as input. Results for one representative sample are shown in FIG. 5. The raw data demonstrates an almost linear increase in signal with increased input material. However, normalized data were nearly identical demonstrating that we can use 100 ng of total RNA as the starting material for the nCounter assay.

In the C-07 discovery cohort the enterocyte subtype in CRCA subtype received benefit from oxaliplatin, however, this signature failed to validate in the independent data set. One reason that the signature failed to validate, may be due to the non-optimal identification of the enterocyte subtype. Our nCounter code set was created before the CRCA subtypes were described and therefore was not designed for subtype identification and unfortunately only includes a very small number of genes for enterocyte identification. Thus accurate identification of the enterocyte subtype was not optimal with the current code set

Another potential problem that may have contributed to the failure to validate our signature was the possibility that other subtypes could include patients who benefited from oxaliplatin. For example the stem-like and TA subtypes may need to be further split into sub-subtypes. TA is heterogeneous group which has a gene expression pattern similar to transit-amplifying progenitor cells which differentiate into goblet and enterocyte cells in the normal colonic crypt. Thus TA may be further refined into sub-subtypes based on their future potential fate, i.e., TA cells that are more likely to differentiate into enterocytes and those that differentiate into goblet. We would hypothesize that only the enterocyte-like subtype within TA would receive benefit from oxaliplatin. However, because our nCounter code set only includes a small number of genes for enterocyte and goblet-like identification, we could not exploit this hypothesis in the nCounter data. We also attempted to split the stem-like subtype but were unable to find a satisfactory split for oxaliplatin benefit in this subtype.

As discussed above, the basis of our previous work is that subtypes have different molecular properties, which determine the degree of benefit they receive from treatment. However, because the identification of CRC subtypes is still in an explorataly phase, it is uncertain how to be identify relevant subtypes for oxaliplatin benefit.

Disclosed herein are a description of the genes and methods for identifying the association of gene modules with CRC subtypes and their association with clinical behavior with an emphasis on identifying patients who receive benefit from oxaliplatin. Identification of modular gene sets and their association to particular CRC subtypes allows not only for subtype identification but also a description of those subtypes, how they are similar and how they are different which will enable a better understanding of clinical behavior,

In the second study, we took a well-established systematic approach, Weighted Gene Correlation Network Analysis (WGCNA), to identify acne modules, i.e., correlated gene expression networks and evaluated how these modules are related to subtypes. Gene modules are generally comprised of functionally related genes. Understanding, the gene modules which characterize subtypes will enable us to understand how each subtype is correlated to each other, and the molecular mechanisms of different prognostic or predictive behavior of each subtype. We have selected genes for a new code set which will enable us to better identify functional, clinically relevant CRC subtypes.

Additional studies profile C-07 with this new code set which provides better understanding of how each module is related to oxaliplatin benefit. Then we reevaluate which current subtype system (among CCS, CRCA, CCMS) is the best for identifying patients that will get benefit from oxaliplatin or we develop a better classification system to define subtypes M terms of oxaliplatin benefit. In addition, we also develop signatures based on other approaches by combining, information obtained from gene module analyses.

Study Design II

We have downloaded the original training datasets for CCS, CCMS and CRCA classifier. The original training dataset for CCS and. CCMS includes 90 and 566 patients respectively. Note the original CRCA training dataset is the combination of two datasets, to avoid the impact of batch effect, in our analyses; we analyzed the two datasets for CRCA analysis separately.

For each dataset, we performed WGCNA analysis on the genes used for the specific classifier. In addition, although these three classifiers all started with genes having large variance, the list of genes is different (FIG. 2). We also performed WGCNA analysis on the union of genes used for all three classifiers (4510). A Venn diagram of genes used for developing subtype classifiers appear in FIG. 6.

WGCNA constructed a network using adjacency matrix, which is constructed by using the soft-threshold approach (II Si on the matrix of pair-wise correlation coefficients. Topological overlap distance was then calculated from the adjacency matrix, and used to build a hierarchical clustering tree. Modules were defined, as branches of a hierarchical clustering tree, with a minimum module size of 50 genes. A module eigengene distance threshold of 0.4 was also used to merge highly similar modules. Each module is assigned a unique color label. For the convenience of comparison, we matched the module colors from different training dataset based on modules identified in CCMS training dataset. WGCNA analysis was done using WGCNA R package

We assigned each patient to different subtype in CCS, CRCA or CCMS clustering system using SSP method, the centroid was obtained from the original publications. We further identified differentially expressed genes for each subtype using SAM method, and plotted such information underneath the WGCNA tree.

Results

For each dataset, we performed WGCNA analysis on the genes used for the specific classifier (data not shown) and the union of genes used for training three classifiers (4510 genes) in the WGCNA analysis in CCMS training datasets. The module colors are assigned by WGCNA algorithm automatically, based on the ranking of module size.

To understand how these modules are related to subtype, information of genes' expression in each subtype was added in the tree plot. In CCMS training dataset( ), six lame modules were: identified, and these gene modules express differently in different subtypes. Turquoise module, the largest module, includes 1424 genes, and most of these over expressed in step-like/ccs3/ CCMS4 and CCMS6. Importantly, the turquoise module contains stromal and epithelial to mesenchyrnal related genes demonstrating the functional information that can be inferred with modular analysis. The black module includes 866 genes, they overexpressed in stem-like/ccs3/CCMS4, and inflammatory/ccs2/CCMS2. The brown module includes 649 genes, overexpressed in inflammatory/ccs/CCMS2. The yellow module includes 613 genes, overexpressed in TA/ccs1/CCMS1/CCMS5. The green module includes 506 genes, doesn't seem to have a clear pattern. The red module includes 451 genes, overexpressed in goblet/CCM3, enterocyte/CC.MS6.

TABLE 4 # Stem- genes Enterocyte Goblet-like Inflammatory like TA Turquoise 1424 + Black 866 + + Brown 649 + Yellow 613 + Green 506 Red 452 + +

Similar analyses were performed for other datasets. For the convenience of comparison, we have matched the module color from other datasets to module colors in CCMS training dataset. As shown in FIG. 3B-D, although modules identified in other datasets are different from modules identified in CCMS training datasets, there is significant overlap for modules identified from different datasets, and these modules have distinct expression pattern in different subtypes.

To identify genes that are preserved in different datasets in terms of module membership, we further laid out the significant overlap modules identified in different datasets in the same tree, i.e., genes that are from modules that don't have significant overlap are colored gray.

The data (not shown) shows significant overlap among modules from other datasets, especially for turquoise and black modules identified from CCMS dataset. For brown, yellow and red modules identified in CCMS dataset, they are moderately preserved in other datasets, and sometimes they were further split into smaller modules. For example, in cos datasets, the brown module in CMS, damset split into both brown and green modules. Gene selection focuses on gene, that are preserved hi modules with particular locus on hub genes, i.e., genes which have strong correlation with a large number of genes.

We have identified a list of genes that will be used for identification of subtypes and sub-subtypes with differential benefit from oxaliplatin Table 6, Genes will be selected from this table to include in our code set to profile C-07, further refinement of the code set will be determined by additional criteria such as a gene's correlation between fresh and FFPE isolated RNA, the preservation in other datasets, and functional analysis.

TABLE 5 Genes for identification of subtypes and sub-subtypes CCMS ccs CRCA1 CRCA2 potential 1 RGL3 black black black gray GABRB2 black gray black black ZDHHC11 turquoise gray gray gray HOTTIP black gray gray gray TCTE3 black gray black black FAM185A black gray black black NKAIN2 turquoise turquoise turquoise gray SV2C turquoise gray turquoise turquoise C17orf78 turquoise turquoise turquoise gray ERVMER34-1 turquoise turquoise turquoise turquoise ZNF395 turquoise gray gray gray NTRK2 brown gray gray gray SH3TC2 turquoise turquoise gray turquoise SLC7A8 turquoise gray gray turquoise LURAPIL turquoise gray gray turquoise EDAR turquoise turquoise turquoise turquoise SLC6A20 black gray gray gray FLVCR1-AS1 brown gray brown brown RUSCI-AS1 turquoise turquoise gray gray LCN15 turquoise gray gray gray PLEKHS1 black black black gray CLDN2 brown brown brown brown CYP4X1 brown green brown brown TRIB1 turquoise gray turquoise turquoise LSS brown green brown gray ZDHHC5 brown green gray gray LRRC8E brown green gray brown OTUB2 brown brown brown brown SCARNA2 yellow gray gray gray CAMTA1 brown gray gray gray IL1A black magenta gray black CCL20 yellow red green red NFKBIZ black black black black ZC3H12A black black black black CXCL1 black black black black CXCL2 black black black black CXCL3 brown brown gray gray C11orf71 black gray black black KRTAP4-1 yellow yellow yellow gray MACROD1 brown green gray gray SAMD12 turquoise gray gray turquoise GABRA2 turquoise gray gray turquoise IRS2 turquoise gray gray gray SLC44A5 green yellow gray red SEC16B green gray yellow gray DEPTOR turquoise turquoise gray turquoise EPPK1 brown green gray gray ALDH7A1 brown green gray gray UTS2 black gray black black MYCN brown gray brown brown CLCN4 black black black gray RGMB brown green brown gray NMNAT3 brown gray gray gray DCDC2 black gray gray gray HIPK2 black gray black gray ANKRD17 green green gray gray HINT3 turquoise gray gray turquoise AIG1 turquoise gray gray gray TPD52L1 brown gray gray gray ERO1L black magenta black gray SPTBN1 black gray black gray CD9 brown green gray gray ENC1 black gray gray gray DNAJC16 brown green gray gray NNT green green gray red LRRC6 brown gray gray gray NETO2 brown green brown brown STK31 green yellow yellow gray EPB41L2 green green gray gray SULT1C2 brown gray gray gray ANKRD18A brown gray gray brown SAMD5 brown gray brown brown NRD1 black gray black gray 6-Mar turquoise gray gray turquoise PLCB1 green yellow yellow gray ZNF678 green yellow yellow red ZNF738 green gray gray gray ZNF702P green gray gray gray DEPDC7 green gray gray yellow ALPK1 green yellow gray gray FAM221A green gray gray red RBM11 green yellow gray red FAM213A green gray gray gray RHOBTB3 green yellow gray gray SLC22A15 green gray gray gray NT5C2 green yellow gray gray ZNF124 green gray yellow red KDM4C green green yellow red RALGPS1 green yellow yellow red TJP2 green yellow gray gray MBOAT2 green gray gray gray VEGFA green green gray gray ZNF320 green gray gray gray EEF1A1 green yellow gray gray TOB1 green yellow gray red PIK3R1 green yellow gray gray GK green gray gray gray MET green yellow gray gray ITPR2 green gray gray gray GRAMD1C green gray gray red DDX26B green gray gray gray PRRG1 green gray gray gray TAF9B green green yellow gray ZNF711 green gray gray gray ZNF614 green yellow gray red TRIM13 green yellow gray red ZNF652 green yellow gray gray ARID2 green yellow yellow red TIPRL green green yellow gray FAM92A1 green gray yellow gray SQLE green green yellow gray LACTB2 green green gray gray NUBPL green yellow yellow red PDE7A green green yellow yellow FAM84B green yellow yellow gray YWHAZ green green gray yellow PDP1 green green gray gray HRSP12 green green yellow gray C8orf59 green green yellow yellow OXR1 green yellow yellow gray ARFGEF1 green green yellow yellow EIF3H green yellow yellow yellow AZIN1 green gray yellow yellow UTP23 green green yellow yellow E2F5 green green yellow gray MED30 green green yellow gray HCG11 green yellow yellow yellow TMEM170B green gray yellow gray ZNF439 green gray gray gray PIWIL4 green yellow yellow red CCDC146 green gray gray gray TMEM245 green yellow yellow gray TAPT1-AS1 green yellow yellow gray ZNF420 green yellow yellow gray SMARCE1 green yellow yellow gray PLA2R1 green yellow yellow gray RBM6 green yellow yellow gray DDX17 green green gray gray EFHC1 green yellow gray gray HERPUD2 green green yellow yellow KLHL7 green gray gray gray 7-Sep green gray yellow gray ENPP5 green yellow yellow red SESN3 green gray gray gray HNMT green gray gray red ZBTB38 green yellow gray red CEP68 green yellow yellow gray RPL15 green yellow yellow red ZNF605 green yellow yellow red KCNH8 green yellow yellow gray GPCPD1 green yellow yellow gray LPCAT2 green gray yellow yellow ORMDL1 green gray gray gray CLHC1 green gray gray gray ASXL2 green yellow gray yellow NR1D2 green yellow yellow gray TULP4 green yellow yellow yellow PAN3-AS1 green yellow yellow yellow ZNF141 green yellow yellow yellow MLLT4-AS1 green yellow yellow yellow ZNF226 green gray gray red ZNF302 green yellow gray red JPX green yellow yellow yellow SKIL green yellow yellow gray MBNL2 green yellow yellow gray PCMTD1 green yellow gray gray TMEM106B green yellow yellow gray ATF6 green yellow gray gray VAMP4 green gray gray gray ANKRD10 green yellow yellow gray NFAT5 green yellow gray yellow TRAF5 green yellow yellow gray ZKSCAN1 green yellow yellow yellow RNF170 green yellow yellow yellow SRSF6 green green yellow yellow RBM26 green yellow yellow yellow MIR17HG green yellow yellow yellow SLC25A27 green yellow yellow yellow AHSA2 green gray gray gray PNISR green yellow gray gray SOS1 green yellow gray gray KIAA0907 green yellow yellow gray ATRX green gray yellow gray MKLN1 green green yellow gray FNBP4 green green gray gray LUC7L3 green yellow yellow gray OGT green green yellow gray MBTD1 green yellow yellow yellow SLC25A36 green yellow yellow yellow ANKRD10-IT1 green yellow yellow yellow COMMD6 green yellow yellow gray DNAJC3-AS1 green yellow yellow yellow DOCK9 green yellow yellow yellow NHLRC3 green yellow yellow yellow UGGT2 green yellow yellow yellow DLEU2 green yellow yellow yellow ARHGEF7 green yellow yellow yellow ZMYM2 green yellow yellow yellow ARGLU1 green yellow gray yellow N4BP2L2 green yellow yellow gray MTRF1 green yellow yellow gray UFM1 green green yellow yellow COG3 green yellow yellow yellow VPS36 green yellow yellow yellow SUPT20H green yellow yellow yellow MED4 green green yellow yellow TUBGCP3 green green yellow yellow CDK8 green green yellow yellow PDS5B green yellow yellow yellow RC3H2 green green gray yellow ZNF44 green yellow gray red MB21D1 green gray gray gray ZNF75A green gray yellow gray C9orf64 green green yellow red ZNF160 green yellow yellow yellow SAMD4B green yellow yellow gray FTX green yellow yellow yellow TUG1 green yellow yellow gray GATAD1 green yellow yellow yellow RAP2A green yellow yellow yellow INO80D green yellow yellow red PHACTR2 green yellow yellow gray PRKCI green yellow yellow yellow ZNF148 green yellow yellow yellow TXNDC9 green yellow yellow yellow LTN1 green yellow yellow red SLC5A3 green yellow yellow yellow ZNF397 green yellow yellow gray ZNF573 green yellow yellow yellow TMEM19 green yellow gray red IL7 green gray gray gray NPNT green gray gray gray GDPD1 green gray gray red RAB2A green yellow gray gray INPP4B green gray gray gray SCARB2 green green gray gray KDM6A green green gray gray B3GALNT2 green green yellow gray LRIG3 green green gray gray SETD9 green gray gray red LONRF1 green yellow yellow gray EFCAB2 green green gray gray NET1 green green gray gray BTBD3 green gray gray gray LINC00342 green gray gray gray CANX green green gray red CDC14B green yellow gray red SYNJ2BP green gray gray red NCOA7 green gray gray gray FZD3 green gray gray gray VMP1 green yellow gray gray ZNF268 green yellow gray red SCAPER green gray gray gray LRIF1 green yellow yellow red ZHX1 green yellow yellow yellow GDAP1 green gray gray gray MBIP green green gray gray KIAA0368 green yellow gray gray NAMPT green gray gray gray DNAJC3 green gray gray gray OTUD3 green green gray gray PPM1L green gray gray gray MLH3 green gray gray gray RAD52 green green gray red MSI2 green green yellow gray B3GNT2 green green gray gray CRYZ green gray gray gray MPZL2 green green gray red ARMC8 green gray gray gray STAMBPL1 green green gray gray RPL31 green gray gray gray CNOT6L green green gray gray BTC green gray gray gray ZNF432 green gray gray gray SLC39A10 green gray yellow gray ACTR2 green green yellow yellow PIGN green green gray gray CDK6 green green gray gray FAM179B green gray gray gray BCKDHB green green gray red PELI1 green gray gray gray STX6 green green gray gray ARHGAP18 green green yellow red PGAP1 green green gray red ITGA2 green gray gray gray ITGA6 green green gray gray SNX25 green green gray gray ZNF112 green yellow gray gray EIF5A2 green gray gray gray HMGN5 green gray gray gray EIF3F green green gray gray DPY19L1 green green gray gray PTPLB green green gray red C1GALT1 green green gray gray RRM2B green green gray gray CEP70 green gray gray gray ADAM9 green green gray gray PDK1 green green gray gray GCH1 green gray gray gray NUCB2 green gray gray gray ASPH green gray gray gray G3BP2 green green gray red ETNK1 green gray gray gray SPTSSA green green gray gray ZADH2 green green gray red KRAS green gray gray gray DYRK2 green yellow gray gray CSNK1A1 green green gray gray ACBD3 green gray gray gray MAP3K5 green gray gray gray SGMS2 green gray gray gray ANP32E green gray gray gray KCTD3 green green gray gray TAF1A green gray gray gray SGMS1 green gray gray gray KATNBL1 green gray gray gray CTDSPL2 green green gray gray DTWD1 green gray gray gray RFX7 green green gray gray FEM1B green green gray gray HECTD1 green gray gray gray SGPP1 green green gray gray FAM102B green gray gray gray BLZF1 green gray gray gray PPP2R5C green gray gray gray SPRED1 green green gray gray UHMK1 green green gray gray RPRD1A green green gray gray MDM2 green green gray gray RGGT1B green green gray gray PRPF39 green green gray gray RBM25 green green gray gray PCNXL4 green gray gray gray EXOC5 green green gray gray STYX green green gray gray ARHGAP5 green green gray gray STRN3 green green gray gray IMPACT green gray gray gray TMOD3 green green gray gray GALNT1 green gray gray gray ANKRD12 green gray gray gray SOCS6 green gray gray gray NAPG green green gray gray MIB1 green gray gray gray ESCO1 green gray gray gray SMCHD1 green gray gray gray MAGT1 green green gray gray MORF4L2 green yellow yellow gray RP2 green green gray gray NXT2 green gray gray gray PIGA green green gray gray RPS24 green green yellow red TPR green green gray gray LPGAT1 green green gray gray PTAR1 green gray gray gray RFX3 green green gray red MYO6 green green gray gray AP1S2 green gray gray gray STK38L green yellow gray gray PTPRG green green gray gray CAPZA2 green green gray gray MYO1B green green gray gray STARD4 green gray gray gray B4GALT6 green gray gray gray GPAM green yellow gray gray SEPSECS green gray gray red PLA2G12A green green gray red CACUL1 green green gray gray NBN green green gray gray ZCCHC7 green yellow gray red GLS green yellow gray gray ATP2C1 green gray gray gray DDX3X green green gray gray SCAMP1 green green gray gray NAA15 green green gray gray API5 green yellow gray gray YME1L1 green gray gray red NF1 green green gray yellow EML4 green green yellow red ADAM1A green yellow yellow red SLC38A1 green yellow yellow red ATP11B green green gray red TBL1XR1 green green gray gray FNIP1 green green yellow red TTC37 green yellow yellow red EEA1 green green yellow gray RAD50 green yellow yellow red PAWR green gray yellow yellow PTBP3 green green gray gray SLC30A9 green gray gray gray PSIP1 green green gray gray SLC4A7 green green gray gray NIPBL green gray gray gray DNAJC10 green gray gray gray CBR4 green yellow gray red BOD1L1 green gray gray gray YTHDC2 green green gray gray MATR3 green green gray red PAPD4 green gray gray gray TRPM7 green green gray red WDR11 green yellow gray gray AFF4 green gray gray gray C5orf24 green green gray gray ATF2 green green gray gray ZFYVE16 green gray gray gray SP3 green yellow yellow yellow TLK1 green green gray red SF3B1 green gray gray gray UBXN4 green green gray gray USP34 green yellow gray gray JMJD1C green gray gray gray RICTOR green green gray gray CLASP2 green yellow gray gray TMEM33 green green gray red DCAF17 green green gray yellow ZNF107 green gray yellow gray WDR36 green green gray gray GPR180 green gray gray gray THAP9-AS1 green green gray gray PPP6R3 green green gray gray KIAA1731 green gray gray gray ARL5B green gray gray gray ZFR green green gray yellow STRN green yellow gray red PDZD8 green green gray gray CHML green gray gray gray ATL2 green green yellow gray HOOK1 green gray gray red SERBP1 green yellow gray gray ANKRD28 green gray gray red G2E3 green gray gray gray KIF21A green gray gray gray UBA6 green green gray gray LIN7C green green gray gray PDS5A green gray gray gray FAR1 green green gray gray PRPF38B green yellow gray gray MYSM1 green green gray red TRMT13 green yellow yellow red ZNF644 green green gray gray LARP4 green green gray gray CEP152 green gray gray gray CBX3 green green yellow yellow CREBZF green green gray gray U2SURP green yellow gray gray RIF1 green gray gray gray SMC3 green gray gray gray TMA16 green green gray gray SEC23IP green green gray gray BBS7 green gray gray gray PAQR3 green gray gray gray DAAM1 green gray gray gray OIP5-AS1 green gray gray gray EIF4A2 green yellow gray gray CCSER2 green gray gray gray NAB1 green green gray gray WSB1 green gray gray gray PRKAR1A green green gray gray MFAP3 green green gray gray POLI green gray gray gray CCDC91 green yellow gray gray USP32P2 green gray gray gray HIPK3 green green gray gray TMEM30A green green gray gray CPEB4 green green gray gray DMXL2 green gray gray gray MBNL1 green green gray gray REEP3 green green gray gray PDE3B green green gray gray EXPH5 green green gray red ACVR1C green gray gray red PPARA green yellow gray red NUDT12 green gray gray red GCNT1 green gray gray red NSUN7 green gray gray red MLLT3 green green gray red APIP green yellow gray red SPAG1 green gray gray red TMEM38B green green yellow red MPP7 green gray gray red IL20RA green yellow yellow red SOWAHC green yellow gray red TMEM170A green green yellow yellow KLF5 green gray yellow red DDAH1 green green gray red HNF4G green green gray red OCLN green green yellow gray GIPC2 green yellow gray red RNF128 green yellow yellow red HSDL2 green gray yellow red GOLIM4 green green gray red KIF5B green green yellow yellow ZBTB18 green green yellow red SLC12A2 green gray gray red STXBP6 green gray gray red IFT74 green gray gray red CXADR green green gray red ADD3 green yellow gray red CERS6 green green gray red SH3YL1 green yellow yellow red NEBL green yellow yellow red CD46 green yellow yellow red TRIM2 green green gray red PRRG4 green green gray red LGALSL green yellow gray red CYP2J2 green gray gray red XK green gray gray red CMAS green gray gray red FAR2 green gray gray red NHSL1 green yellow gray red PFKFB2 green gray gray red FAM110C green yellow gray red HSD17B11 green gray gray red AKAP7 green gray gray red TMEM56 green gray gray red KIAA1244 green gray gray red RASEF green gray gray red DENND1B green gray gray red FGD4 green green gray red CYP3A5 green gray gray red RABGAP1L green gray gray red EDEM3 green gray gray red RASSF6 green gray gray red HIGD1A green gray gray gray PTP4A1 green green gray red TMEM144 green green gray red ITGB6 green gray gray red FAM13A green gray gray red ANK3 green gray gray red SLC40A1 green gray gray red CDC42SE2 green gray gray red SLC35F5 green gray yellow red WASL green green gray gray AKAP9 green yellow gray red NAPEPLD green yellow gray red LAMTOR3 green gray gray gray MIER3 green green gray red PPP1CB green yellow gray gray LNX1 green gray gray red MTM1 green green gray red MECOM green yellow gray red EHF green green gray red SLC35B3 green gray gray red STL2 green gray gray red MOB3B green gray gray red ARL14 green gray gray red SLC16A9 green gray gray red SAMD13 green gray gray red NIPAL1 green gray gray red SUCLG2 green green gray red TDP2 green gray gray red LRRC31 green gray gray red STX19 green gray gray red SLC44A1 green yellow gray red KRCC1 green gray gray red TRIQK green gray gray red TM9SF3 green yellow gray red DSGZ green gray gray red C4orf33 green gray gray red FRYL green gray gray red ARFIP1 green green gray red USP53 green gray gray red TPD52 green gray gray gray FAM135A green yellow gray red CD164 green green gray red KLF3 green green gray red ABCD3 green gray gray red GALNT3 green gray gray red CLCN3 green green gray red CDS1 green gray gray red GALNT7 green green gray red SLC35A3 green gray gray red TUBBP5 brown green gray gray SIM2 brown green gray brown MESP1 brown gray brown brown DHRS2 brown gray brown brown RBBP9 brown gray gray gray CDS2 brown green gray gray TRMT6 brown green gray brown ANKEF1 brown green gray gray CSNK2A1 brown gray gray gray MKKS brown green gray gray CRLS1 brown gray gray gray SNX5 brown green gray gray CRNKL1 brown gray gray gray CSRP2BP brown gray gray gray KIF16B brown gray gray gray MMAA brown gray gray brown CXorf57 brown brown gray gray LINC00467 brown gray gray brown CCND1 brown green gray brown GDF15 brown green gray brown M6PR brown green gray gray EPHB3 brown green gray brown CNTNAP2 brown gray brown brown LRRC34 brown gray gray gray STC2 brown gray gray gray HAS3 brown gray brown brown AP1S1 brown green gray brown DMRT2 brown gray gray gray SLC29A1 brown green gray gray HMGCS1 brown green brown brown INSIG1 brown green brown brown ZNF850 brown gray gray gray ANKRD22 brown green gray brown FAM222A brown gray brown brown CHDH brown gray gray gray KIF1B brown gray gray gray SYBU brown gray gray gray COX7B brown green gray gray LDLR brown brown gray gray GOLT1A brown gray brown brown CYB5R2 brown gray gray gray KDM3B brown green gray gray HS6ST2 brown gray gray brown FDFT1 brown green brown brown FUOM brown gray gray brown ERLIN2 brown gray gray gray FAM83B brown green gray brown CDH3 brown green brown brown CA5BP1 brown brown gray gray SLC16A1 brown green brown brown MSX1 brown gray brown brown PITX2 brown gray gray brown KIAA1257 brown gray gray brown AP2B1 brown gray brown brown DLG3 brown green gray brown PROCR brown gray gray gray RHPN2 brown gray gray gray AIM1 brown gray brown brown PREP brown green gray gray CRNDE brown green gray brown HMGA2 brown green gray brown PDK3 brown gray brown gray SOX12 brown green brown brown ART3 brown brown gray gray GRAMD2 brown gray gray gray PROM2 brown gray gray brown NSF brown gray gray gray TNS4 brown brown gray brown VSNL1 brown gray brown brown SMYD2 brown gray brown brown PODXL2 brown green brown brown C1orf53 brown green gray brown FAHD1 brown gray gray gray BAX brown green gray brown PHLPP1 brown green gray brown HOMER1 brown gray brown brown UGGT1 brown green gray gray GRHL1 brown gray brown brown KISS1R brown gray gray gray 1-Mar brown green gray brown SLC27A5 brown brown gray brown EPHX4 brown gray gray gray NAP1L1 brown green brown gray ASB9 brown brown gray gray SLC35A2 brown green gray brown HSD17B10 brown gray gray gray PDHA1 brown gray gray gray RNFT2 brown brown brown gray DIS3L2 brown gray gray brown ACAT1 brown brown brown gray OR7E14P brown brown gray brown ABHD11 brown green gray brown YWHAE brown green gray brown CTH brown brown gray brown TAF15 brown gray brown brown PDCD6 brown gray brown brown MANEAL brown green brown brown SLCO4A1 brown gray brown brown MSL2 brown green gray brown NFATC3 brown gray brown brown BIK brown green gray brown MTMR1 brown green gray gray C2CD4A brown brown gray brown ENSA brown green brown gray DNAJC14 brown green brown gray GLS2 brown green gray brown CBFB brown green gray gray TM7SF3 brown green gray brown PRKX brown green gray gray GDI2 brown green brown brown GSR brown green brown brown MFHAS1 brown green brown brown PPP2R2A brown gray gray brown UBXN8 brown gray brown brown AGPAT5 brown brown brown brown CNOT7 brown green brown brown SF1 brown gray brown gray SUMF2 brown green gray brown PRCC brown green brown gray HYOU1 brown green gray gray EIF5A brown green gray brown SIN3A brown green gray brown GLUD1 brown green gray gray RAB8A brown green gray gray YWHAH brown green brown gray CDK9 brown green gray brown DCAKD brown green gray brown EXOSC6 brown green gray brown PDIA4 brown green brown brown PPIB brown green brown brown HNRNPL brown green gray brown COPG1 brown green gray brown STT3A brown green brown brown RPN1 brown green gray brown SNRNP40 brown green brown brown FAM169A brown brown gray brown CCDC47 brown green brown brown PLEKHG4 brown gray gray gray BAG5 brown green gray brown F12 brown brown brown brown DLGAP1-AS2 brown gray gray gray MCCC2 brown green brown brown TGIF1 brown gray gray brown MLEC brown green brown gray THRAP3 brown gray brown brown ST7L brown gray gray gray HES6 brown gray brown brown SMKR1 brown green brown brown MEX3D brown green brown gray STEAP3 brown green brown gray AJUBA brown gray brown brown GSTO2 brown brown brown brown LIMD1 brown green gray gray CDKAL1 brown green gray brown ATP5S brown gray gray brown TCTEX1D2 brown brown brown gray MPP6 brown gray brown brown MOB1A brown green brown brown RAB6A brown green brown brown PDSS2 brown gray brown gray SAFB brown green gray gray SLC1A4 brown green brown gray TRIB3 brown gray gray brown CBX2 brown green brown brown ELOVL7 brown brown gray brown PSMC2 brown green brown brown EIF3B brown gray gray gray TRRAP brown green brown gray MCM3AP-AS1 brown gray gray gray PMAIP1 brown gray gray brown C12orf75 brown green gray brown PITX1 brown green brown brown RPL35A brown gray brown gray FBXO41 brown green gray gray CRKL brown green brown brown AKIRIN1 brown green gray gray PPP3R1 brown green brown brown CTNNB1 brown green gray gray HNRNPH1 brown green gray brown CCDC117 brown green brown brown TRA2A brown gray gray brown KDM1B brown gray brown brown IL17RB brown brown brown brown SSR1 brown green gray brown DHCR24 brown brown brown brown PKP4 brown green gray gray SLC7A11 brown gray gray brown SUMO2 brown green gray brown RBBP5 brown green gray brown TLCD1 brown gray gray brown APOBEC3B brown brown gray brown SLC35F2 brown brown brown brown BTG3 brown gray brown brown SUDS3 brown green gray gray NCEH1 brown green gray brown RAB15 brown green gray gray TMEM52 brown green brown brown SLC43A1 brown green brown brown AIFM2 brown brown brown brown HDAC8 brown brown gray gray ZNF239 brown gray brown gray RAP1GDS1 brown gray brown brown H2AFY brown gray gray brown PGK1 brown gray brown brown ZNF207 brown gray brown brown HPDL brown gray brown brown DNAH14 brown gray gray brown RAB3IP brown brown gray gray PIR brown brown brown brown CISD2 brown brown brown brown ITCH brown green gray gray AP1S3 brown brown brown brown ARNTL2 brown gray gray brown CCNO brown brown brown brown CDC25B brown green brown brown TCF3 brown green brown brown TRMU brown brown brown brown MAT2A brown green gray brown THNSL1 brown brown brown brown RSL1D1 brown brown gray brown TAF11 brown green gray brown CD47 brown gray gray brown FDXR brown green gray brown KBTBD8 brown brown brown brown C14orf2 brown brown brown brown EMC1 brown green gray brown PGD brown green brown brown GCHFR brown brown brown brown CENPV brown green brown brown PCSK9 brown brown brown brown FUS brown green brown brown MAP3K9 brown brown gray brown FAM210A brown brown brown brown FAM201A brown green brown brown CASP2 brown green brown brown SHMT1 brown green brown brown BAG4 brown brown gray gray ZNF511 brown brown brown brown SRD5A1 brown green brown brown LARP1 brown green brown gray NT5DC2 brown green brown brown PHKA1 brown gray brown gray DESI1 brown green brown brown JPH1 brown green brown brown CCDC58 brown brown brown brown STRIP2 brown brown brown brown VDAC1 brown green brown brown XPNPEP3 brown gray brown gray SEC23B brown gray gray gray APOOL brown gray gray brown DHCR7 brown green brown brown FAM57A brown gray gray brown MRPL2 brown green gray gray CDV3 brown green brown brown KCMF1 brown green brown brown PHGDH brown brown gray brown MNS1 brown brown brown brown PRRT3-AS1 brown brown brown brown PIGL brown green brown brown EBP brown gray brown brown IDH2 brown green brown brown RRP7A brown brown brown brown TMED2 brown green brown brown TFRC brown green brown brown SORD brown green brown brown AK2 brown brown brown brown MORC4 brown brown brown brown MYBBP1A brown green gray brown HNRNPA1 brown green brown gray NANP brown gray gray gray FLVCR1 brown brown gray gray MCM8 brown gray gray brown PRTFDC1 brown gray brown gray WEE1 brown green brown gray LARS2 brown gray brown gray PRMT6 brown green gray gray PRPS1 brown brown brown gray IDH3A brown green brown brown PEX13 brown green gray brown DDT brown green brown brown NAP1L4 brown green brown brown ARG2 brown brown brown brown RPP25 brown brown brown brown LSM12 brown green brown brown GPHN brown brown brown brown C5orf22 brown green gray brown PSMG4 brown gray gray brown APOO brown brown brown brown DCAF16 brown gray gray gray B9D1 brown brown gray brown SNRNP48 brown brown brown brown LYPD6 brown brown brown brown HN1 brown green brown brown UBE2I brown gray brown brown BOP1 brown green brown brown SLC3A2 brown green gray brown FAM216A brown brown brown brown ODF2 brown green brown brown SCAF4 brown gray brown gray NUP62 brown green gray gray FH brown green brown brown FASN brown green brown brown FUT4 brown brown brown brown SRPRB brown green brown brown NDUFS1 brown green brown brown LIPG brown green brown brown MRPS25 brown gray brown brown EIF4EBP1 brown brown brown brown MRPL52 brown green brown brown PRMT5 brown gray brown brown PSMB5 brown green brown brown THOC6 brown green brown brown MIF brown green brown brown ENO1 brown green brown brown LSM2 brown green brown brown GADD45GIP1 brown green brown brown MRPS12 brown green brown brown TIMM50 brown green brown brown ALYREF brown green brown brown TOMM22 brown green brown brown UBE2M brown green brown brown YIF1B brown green brown brown ACAT2 brown brown brown brown QRSL1 brown gray gray brown ANKRD36 brown gray brown brown DUT brown brown brown brown HBS1L brown green brown brown C18orf54 brown brown brown brown MTHFD2L brown brown brown brown AADAT brown brown brown brown CDCA7L brown brown brown brown PRKDC brown green gray brown PPID brown gray gray brown XRCC5 brown gray gray brown EIF4E brown green brown brown ASNS brown brown brown brown SMS brown green brown brown NRF1 brown gray brown brown BICD1 brown gray gray brown SFR1 brown green gray brown MRPL44 brown green brown brown MTFMT brown green brown brown GNPNAT1 brown brown brown brown DNAAF2 brown green brown brown TMX1 brown green gray brown CAND1 brown gray gray brown RBBP8 brown brown gray brown RNF138 brown brown gray brown TIMM21 brown brown gray brown CHAC2 brown brown brown brown GEMIN2 brown brown brown brown CEP76 brown brown brown brown SEH1L brown brown brown brown GLE1 brown green brown brown SFXN1 brown brown brown brown SGOL1 brown gray brown brown FARSB brown gray brown brown SET brown gray brown brown TRNT1 brown green brown brown PSPH brown green gray brown ACLY brown green brown gray ORC5 brown green brown brown FAM161A brown brown brown brown STRAP brown gray brown brown AMMECR1 brown green gray brown RNASEH2B brown gray gray gray CENPJ brown brown gray brown DIS3 brown gray gray brown NUDT15 brown brown gray brown IPO5 brown green gray brown BRCA2 brown green gray brown MZT1 brown brown gray brown EXOSC8 brown brown gray brown BORA brown brown gray brown CKAP2 brown brown gray brown HNRNPC brown gray brown brown SLC7A5 brown gray gray brown PRPS2 brown gray gray gray LRP8 brown brown brown brown ZNF165 brown brown gray brown C1orf174 brown gray gray brown SAP30 brown brown brown gray CTNNAL1 brown brown brown brown TKT brown green brown brown MRPL50 brown green brown brown PSMG1 brown green brown brown TMEM237 brown gray brown gray NUP50 brown green brown brown FGFR1OP brown green brown brown SPIN4 brown gray gray brown NSMCE4A brown green brown brown NUP210 brown green brown brown UTP20 brown green brown brown WDR4 brown brown brown brown NUP62CL brown brown brown brown GAS2L3 brown brown brown brown SMC1A brown brown gray brown SHMT2 brown green brown brown HSPA4 brown gray brown brown POLR3G brown brown brown brown RRP15 brown gray brown brown SPATA5L1 brown brown brown brown HAUS1 brown brown brown brown GPT2 brown brown brown brown ADK brown green gray brown ELAVL1 brown green brown brown HSPA9 brown green brown brown TBC1D30 brown brown brown brown HNRNPU brown gray gray brown PAK6 brown green brown brown RMI2 brown brown brown brown TUBA4A brown green brown brown KIF9 brown brown brown brown CHRNA5 brown brown brown brown MARS2 brow green brown brown WDR34 brow brown brown brown PPM1G brow green brown brown RBM14 brow green brown brown HSPD1 brow gray brown brown EED brow gray brown brown SUPT16H brow green brown brown TMEM97 brow green brown brown ILF3 brow green brown gray GART brow gray brown brown CDC23 brow brown brown brown HMGB3 brow green gray brown NCBP1 brow green brown brown PSMA5 brow gray brown brown ESCO2 brow brown brown brown WDR76 brow brown brown brown CCDC150 brow brown brown brown SAC3D1 brow brown brown brown METTL21A brow gray brown brown C1QBP brow green brown brown TSR1 brow green brown brown MRS2 brow brown brown brown BRI3BP brow brown brown brown RNASEH1 brow green brown brown SKA2 brow brown brown brown PHF19 brow brown brown brown NUP98 brow green brown brown LSM4 brow green brown brown PSAT1 brow brown brown brown TYMS brow brown brown brown GSPT1 brow gray gray brown NUP43 brow green gray brown TFDP1 brow brown gray brown G3BP1 brow green brown brown WDR43 brow brown brown brown FANCA brow brown brown brown GRPEL2 brow green brown brown IQGAP3 brow brown brown brown RAD54B brow brown brown brown FIGNL1 brow green gray brown RAD18 brow brown brown brown PRIM2 brow green brown brown RCC1 brow brown brown brown TFAM brow green gray brown BCCIP brow brown brown brown USP1 brow brown brown brown GINS1 brow brown gray brown PPAT brow brown brown brow YEATS4 brow green brown brow SRSF1 brow green brown brow CACYBP brow brown brown brow SNRPD1 brow brown brown brow TMPO brow green brown brow CDK2 brow green brown brow NUDT5 brow green brown brow H2AFX brow brown brown brow MCM5 brow brown brown brow LMNB2 brow green brown brow MCM7 brow brown brown brow CENPI brow brown gray brow DHX9 brow gray brown brow TMEM194A brow green brown brow CENPH brow green brown brow SKA3 brow brown gray brow DIAPH3 brow brown gray brow RFC3 brow brown gray brow RANBP1 brow green brown brow GMNN brow brown brown brow brow CEP78 brow brown brown brow brow C1orf112 brow brown brown brow brow DHFR brow brown brown brow brow SFPQ brow green brown brow brow WHSC1 brow green brown brow brow C4orf46 brow green brown brow brow ATAD2 brow brown brown brow brow CCNE2 brow brown brown brow brow CDCA2 brow brown brown brow brow CPSF6 brow green brown brow brow ZWILCH brow brown brown brow brow KIAA1524 brow brown brown brow brow MASTL brow brown brown brow brow SMC2 brow brown brown brow brow KIF14 brow brown brown brow brow CENPK brow brown brown brow brow CENPE brow brown brown brow brow SGOL2 brow brown brown brow brow PSRC1 brow brown brown brow brow BUB3 brow green brown brow brow ARHGAP11 brow brown brown brow brow CENPW brow brown brown brow brow NASP brow brown brown brow brow CDC7 brow brown brown brow brow LMNB1 brow green brown brow brow SKA1 brow brown brown brow brow TIPIN brow brow brow brow brow PBK brow brow brow brow brow ERCC6L brow brow brow brow brow NEIL3 brow brow brow brow brow WDHD1 brow brow brow brow brow MCM4 brow gree brow brow brow MIS18A brow brow brow brow brow MCM3 brow gree brow brow brow AUNIP brow brow brow brow brow UHRF1 brow gree brow brow brow CDC25A brow gree brow brow brow CENPM brow brow brow brow brow CDC6 brow gree brow brow brow CDT1 brow gree brow brow brow TACC3 brow brow brow brow brow GINS2 brow brow brow brow brow TK1 brow brow brow brow brow E2F7 brow brow brow brow brow RAD51 brow brow brow brow brow FOXM1 brow brow brow brow brow KIF18B brow brow brow brow brow PLK1 brow brow brow brow brow ORC1 brow brow brow brow brow CDCA8 brow brow brow brow brow RRM2 brow brow brow brow brow KIF20A brow brow brow brow brow OIP5 brow brow brow brow brow PRC1 brow brow brow brow brow AURKB brow brow brow brow brow CCNB1 brow brow brow brow brow CDC20 brow brow brow brow brow KIF4A brow brow brow brow brow CDC45 brow brow brow brow brow FEN1 brow brow brow brow brow MTFR2 brow brow brow brow brow BIRC5 brow gree brow brow brow CDCA5 brow brow brow brow brow KIF2C brow brow brow brow brow MCM10 brow brow brow brow brow NCAPH brow brow brow brow brow SKP2 brow gree brow brow brow CKS2 brow brow brow brow brow HELLS brow brow brow brow brow BRIP1 brow brow brow brow brow POLQ brow brow brow brow brow E2F8 brow brow brow brow brow PARPBP brow brow brow brow brow NDC80 brow brown brow brow brow ECT2 brow gray brow brow brow KNSTRN brow brown brow brow brow MKI67 brow brown brow brow brow TOP2A brow brown brow brow brow DBF4 brow brown brow brow brow EZH2 brow brown brow brow brow CASC5 brow brown brow brow brow VRK1 brow brown brow brow brow DNA2 brow brown brow brow brow HMMR brow brown brow brow brow HMGB2 brow brown brow brow brow FBXO5 brow brown brow brow brow KIF18A brow brown brow brow brow ASPM brow brown brow brow brow CDK1 brow brown brow brow brow NUF2 brow brown brow brow brow KIF15 brow brown brow brow brow CENPN brow brown brow brow brow KIAA0101 brow brown brow brow brow CHEK1 brow brown brow brow brow UBE2T brow brown brow brow brow NCAPG2 brow brown brow brow brow RAD51AP1 brow brown brow brow brow ZNF367 brow brown brow brow brow CDKN3 brow brown brow brow brow POLE2 brow brown brow brow brow DTL brow brown brow brow brow STIL brow brown brow brow brow ANLN brow brown brow brow brow MND1 brow brown brow brow brow PLK4 brow brown brow brow brow DEPDC1 brow brown brow brow brow TTK brow brown brow brow brow SPC25 brow brown brow brow brow MAD2L1 brow brown brow brow brow NCAPG brow brown brow brow brow DEPDC1B brow brown brow brow brow DLGAP5 brow brown brow brow brow KIF11 brow brown brow brow brow NEK2 brow brown brow brow brow EXO1 brow brown brow brow brow CEP55 brow brown brow brow brow NUSAP1 brow brown brow brow brow CCNA2 brow brown brow brow brow KIF23 brow brown brow brow brow CCNB2 brow brown brow brow brow ZWINT brown brown brown brown brown BUB1 brown brown brown brown brown BUB1B brown brown brown brown brown LMO7 yellow yellow yellow gray yellow EFNA3 yellow yellow yellow red yellow TMEM187 yellow yellow yellow gray yellow LINC00526 yellow yellow green red yellow LINC00667 yellow yellow green red yellow CAPN3 yellow yellow yellow red yellow MACROD2 yellow yellow yellow gray yellow MFAP3L yellow gray gray gray yellow UNC93A yellow yellow gray gray yellow EYA1 yellow yellow yellow gray yellow GRIP1 yellow gray yellow gray yellow ARSD yellow yellow green red yellow KIAA1211L yellow red yellow red yellow THNSL2 yellow yellow yellow red yellow UCA1 yellow yellow yellow yellow yellow SCML4 yellow yellow gray red yellow CCND2 yellow gray green red yellow ESRRG yellow yellow yellow gray yellow ATF7IP2 yellow gray yellow gray yellow ZNF608 yellow gray yellow yellow yellow FGFRL1 yellow yellow yellow yellow yellow SLC38A4 yellow yellow yellow red yellow SLC52A3 yellow red green red yellow MAVS yellow yellow green red yellow RRBP1 yellow gray yellow red yellow PALD1 yellow gray yellow yellow yellow SMG7 yellow gray yellow yellow yellow CAPN10 yellow yellow yellow gray yellow ZNF682 yellow yellow yellow gray yellow SMAD6 yellow red yellow red yellow NYNRIN yellow yellow green red yellow SULT2B1 yellow yellow yellow red yellow CAMKK2 yellow yellow yellow gray yellow RAB11FIP1 yellow gray gray red yellow TMEM139 yellow red green red yellow BMP7 yellow gray yellow gray yellow GPR115 yellow yellow yellow gray yellow PLBD1 yellow red green red yellow CYP4F11 yellow yellow green red yellow SYK yellow yellow yellow red yellow PERP yellow gray yellow yellow yellow CAPN13 yellow yellow green red yellow L3MBTL4 yellow yellow gray gray yellow ELF5 yellow yellow yellow gray yellow IGF2R yellow gray yellow gray yellow KANSL1 yellow yellow yellow gray yellow PRSS33 yellow yellow yellow yellow yellow ADRBK2 yellow gray yellow gray yellow CLYBL yellow yellow green red yellow CRYL1 yellow red yellow red yellow GLYR1 yellow yellow yellow gray yellow COL9A1 yellow yellow yellow gray yellow ZNF503-AS1 yellow red green red yellow CHRM3 yellow gray gray gray yellow IGF2BP2 yellow yellow yellow yellow yellow BEX2 yellow yellow green gray yellow SCD yellow gray yellow gray yellow PYGB yellow yellow gray red yellow SPATC1L yellow yellow gray gray yellow MROH1 yellow gray gray yellow yellow SLC39A4 yellow yellow yellow gray yellow SLC52A2 yellow gray yellow gray yellow KRT40 yellow yellow yellow gray yellow CYP39A1 yellow yellow green red yellow CADPS yellow yellow green red yellow PCLO yellow yellow yellow red yellow KAZN yellow yellow green yellow yellow C6orf223 yellow yellow yellow gray yellow PLAG1 yellow yellow gray gray yellow ZNF813 yellow gray gray yellow yellow TP53TG1 yellow yellow yellow red yellow QPCT yellow yellow yellow red yellow ZNF827 yellow yellow yellow red yellow EIF3C yellow yellow yellow red yellow SLC35E4 yellow yellow yellow red yellow FAM3B yellow yellow yellow red yellow FOXA2 yellow gray yellow red yellow CAMK1D yellow yellow green red yellow CYFIP2 yellow yellow yellow red yellow MYEF2 yellow yellow yellow gray yellow ARL11 yellow yellow gray gray yellow RNF182 yellow yellow yellow yellow yellow EFNA1 yellow gray green red yellow PLEKHB1 yellow yellow yellow gray yellow ZFP36L2 yellow gray gray yellow yellow SOX9 yellow gray yellow red yellow HKDC1 yellow red yellow gray yellow RASSF10 yellow yellow yellow red yellow RAB11FIP3 yellow yellow yellow gray yellow ME3 yellow yellow yellow red yellow TNMD yellow yellow yellow gray yellow PVR yellow gray yellow red yellow ACOX2 yellow yellow green red yellow ZNF506 yellow yellow gray gray yellow SHISA9 yellow yellow yellow gray yellow MCF2L yellow yellow yellow yellow yellow RNLS yellow yellow green red yellow CCDC170 yellow yellow yellow red yellow OXGR1 yellow yellow green gray yellow VANGL2 yellow yellow yellow yellow yellow FOXQ1 yellow gray yellow yellow yellow SLC17A9 yellow yellow yellow yellow yellow CGREF1 yellow yellow yellow yellow yellow ABCC1 yellow gray yellow yellow yellow ABCC4 yellow gray yellow yellow yellow ZNF529 yellow yellow yellow gray yellow ZNF606 yellow yellow green red yellow ZNF502 yellow yellow green gray yellow SLC11A2 yellow red yellow red yellow SLC13A2 yellow yellow green red yellow SH3BP4 yellow yellow yellow red yellow MGAT5 yellow yellow yellow red yellow MYO10 yellow yellow yellow red yellow MPC2 yellow gray green red yellow PCTP yellow yellow yellow red yellow HDHD1 yellow yellow yellow red yellow PNPLA4 yellow yellow gray red yellow FCGRT yellow yellow yellow gray yellow TMEM176A yellow gray yellow gray yellow TMEM176B yellow gray yellow gray yellow ABCB1 yellow yellow green red yellow JUN yellow yellow yellow gray yellow FGFR3 yellow yellow green red yellow SDR42E1 yellow yellow green red yellow ALDH4A1 yellow yellow yellow gray yellow AZGP1 yellow yellow yellow yellow yellow RPS15A yellow yellow yellow gray yellow DENND1A yellow gray gray red yellow SLC22A3 yellow yellow yellow yellow yellow CHPT1 yellow yellow yellow red yellow C7orf31 yellow gray yellow red yellow C11orf1 yellow gray yellow red yellow CAMK2N1 yellow yellow yellow yellow yellow GPC4 yellow gray yellow red yellow CXXC4 yellow yellow yellow gray yellow RAB40B yellow yellow gray red yellow GSPT2 yellow yellow green red yellow ELAVL2 yellow yellow yellow red yellow PLAGL1 yellow yellow green red yellow SLC35D3 yellow yellow yellow gray yellow IP6K2 yellow yellow yellow red yellow ZNF814 yellow yellow yellow red yellow UNC5CL yellow yellow yellow yellow yellow EVPL yellow yellow yellow red yellow SLC1A7 yellow yellow yellow red yellow ANKH yellow gray yellow red yellow KANK1 yellow yellow yellow red yellow NEURL1B yellow yellow green gray yellow SHH yellow yellow green red yellow PAQR5 yellow yellow green red yellow AMT yellow yellow green gray yellow EFNA2 yellow red green red yellow MYO15B yellow yellow green red yellow TMC5 yellow red green red yellow CGN yellow red green red yellow PTK6 yellow red yellow yellow yellow CC2D1A yellow gray green red yellow MYH14 yellow red green red yellow CYP2S1 yellow yellow green red yellow MGAT4B yellow gray green red yellow LRP4 yellow yellow green red yellow KLC4 yellow yellow yellow red yellow ARHGAP44 yellow red gray red yellow PCK1 yellow red green red yellow SEMA6D yellow red green red yellow SEMA6A yellow red green red yellow SLC26A2 yellow red green red yellow TRPM6 yellow yellow green red yellow SORT1 yellow gray green red yellow ID1 yellow red green red yellow GPR39 yellow red yellow red yellow LEFTY1 yellow red green red yellow CKB yellow red green red yellow PAQR8 yellow red green red yellow KIAA1161 yellow red green red yellow OLFM4 yellow red green red yellow ZSWIM5 yellow red green red yellow TOX3 yellow gray green red yellow WNK2 yellow yellow green red yellow B3GNT3 yellow red green red yellow ARHGEF5 yellow yellow yellow red yellow CLDN4 yellow red yellow red yellow PHYH yellow yellow green red yellow PIWIL2 yellow red green red yellow ABCC6 yellow yellow yellow red yellow CCRL2 yellow red green red yellow ACSF2 yellow yellow green red yellow TGOLN2 yellow yellow yellow yellow yellow HTATIP2 yellow gray yellow red yellow H2AFJ yellow yellow yellow red yellow CEACAM1 yellow red green red yellow SORL1 yellow yellow green red yellow RALGAPA2 yellow yellow green red yellow KCNQ1 yellow yellow yellow red yellow PRR5L yellow red green red yellow ARSE yellow yellow green red yellow WNK4 yellow red green red yellow FAM171A1 yellow yellow green red yellow CEACAM6 yellow red green red yellow GALNT6 yellow yellow yellow red yellow ENPP3 yellow yellow green red yellow PTPRD yellow yellow green red yellow GRM8 yellow yellow green red yellow PTPRK yellow yellow yellow red yellow ZNF704 yellow yellow green red yellow LY75 yellow yellow yellow red yellow SEMA3C yellow yellow green gray yellow STK38 yellow yellow yellow red yellow IYD yellow yellow green red yellow NUDT4 yellow yellow yellow red yellow AUTS2 yellow yellow green red yellow DIAPH2 yellow yellow green yellow yellow PRLR yellow yellow yellow red yellow SEMA5A yellow yellow green red yellow CTTNBP2 yellow yellow green red yellow PLCB4 yellow red yellow red yellow REPS2 yellow red green red yellow FAM105A yellow red green red yellow SATB2-AS1 yellow yellow green red yellow PRKAB1 yellow red green red yellow HMGCS2 yellow red green red yellow CXCL14 yellow yellow green red yellow TSPAN12 yellow yellow green red yellow HEPH yellow red green red yellow POF1B yellow red green red yellow LINC00483 yellow red green red yellow MOGAT3 yellow yellow green red yellow GJB1 yellow yellow green red yellow ETS2 yellow gray green red yellow CASP6 yellow red green red yellow GLCE yellow yellow green red yellow PANK1 yellow red green red yellow GPX2 yellow yellow yellow red yellow ERBB3 yellow red yellow red yellow ST14 yellow red green red yellow PPARG yellow red green red yellow ILDR1 yellow red green red yellow SPINK1 yellow red green red yellow SGK2 yellow yellow green red yellow ACOX1 yellow yellow green red yellow MYO1D yellow gray green red yellow KALRN yellow red green red yellow MUC12 yellow yellow green red yellow KRT20 yellow red green red yellow PIGZ yellow red green red yellow NAT2 yellow red green red yellow FAM134B yellow red green red yellow PBLD yellow red green red yellow SELENBP1 yellow red green red yellow PLEKHG6 yellow yellow green red yellow TINAG yellow yellow green red yellow SOWAHA yellow yellow green red yellow CEBPA yellow yellow green red yellow TFCP2L1 yellow yellow green red yellow ELF3 yellow red green red yellow EPS8L3 yellow red green red yellow CDH17 yellow red green red yellow CEACAM5 yellow red green red yellow PRSS8 yellow red green red yellow TMPRSS2 yellow red green red yellow A1CF yellow yellow green red yellow MUC20 yellow yellow green red yellow NOX1 yellow red green red yellow TRABD2A yellow yellow green red yellow CDH1 yellow gray green red yellow CLDN3 yellow red green red yellow DAPK2 yellow yellow green red yellow SHROOM1 yellow yellow green red yellow MEP1A yellow red green red yellow OVOL1 yellow yellow green red yellow ISX yellow yellow green red yellow ACE2 yellow yellow yellow red yellow SLC39A5 yellow yellow green red yellow SLC3A1 yellow yellow green red yellow CDHR1 yellow yellow green red yellow PPP1R14C yellow yellow green red yellow SATB2 yellow yellow green red yellow ACSL5 yellow yellow green red yellow VIL1 yellow yellow green red yellow DDC yellow yellow green red yellow CFTR yellow yellow green red yellow AIFM3 yellow yellow green red yellow SLC26A3 yellow red green red yellow EPB41L4B yellow yellow green red yellow LRRC19 yellow red green red yellow FABP1 yellow red green red yellow C10orf99 yellow red green red yellow PPP1R14D yellow yellow green red yellow NR1I2 yellow yellow green red yellow PRR15 yellow yellow green red yellow CDX2 yellow yellow green red yellow IHH yellow yellow green red yellow FAM84A yellow red green red yellow ATP10B yellow yellow green red yellow GPR160 yellow yellow green red yellow GUCY2C yellow yellow green red yellow SCARB1 yellow yellow yellow red yellow ZBED3 yellow gray yellow gray yellow TMEM63A yellow gray yellow yellow yellow ATAT1 yellow yellow yellow yellow yellow PTP4A3 yellow yellow yellow yellow yellow ABHD12 yellow yellow yellow yellow yellow HNF4A yellow yellow yellow gray yellow ATP7B yellow yellow yellow red yellow GRTP1 yellow red yellow gray yellow STK24 yellow gray yellow yellow yellow CELSR3 yellow yellow yellow yellow yellow TBC1D5 yellow yellow yellow gray yellow KLHDC10 yellow gray yellow yellow yellow C20orf196 yellow yellow green red yellow LINC00525 yellow yellow yellow yellow yellow DNAJC15 yellow yellow yellow yellow yellow FAM210B yellow yellow yellow yellow yellow RPS6KA6 yellow yellow yellow red yellow CCDC113 yellow yellow yellow red yellow GYLTL1B yellow yellow yellow gray yellow PROSER2 yellow yellow yellow red yellow SNTB1 yellow gray yellow yellow yellow SLC2A4RG yellow yellow yellow yellow yellow NOTCH1 yellow yellow yellow red yellow SOX4 yellow yellow yellow yellow yellow CSNK1E yellow gray yellow gray yellow ZNF503 yellow gray yellow gray yellow SLC6A6 yellow gray yellow gray yellow FARP1 yellow yellow yellow gray yellow PMEPA1 yellow yellow yellow gray yellow LGR5 yellow gray yellow red yellow STX3 yellow gray green red yellow WIF1 yellow yellow yellow yellow yellow HIBADH yellow gray yellow yellow yellow MED1 yellow gray yellow yellow yellow CLDN1 yellow yellow yellow yellow yellow ZNF280B yellow yellow yellow red yellow AOAH yellow yellow yellow gray yellow RNF157 yellow yellow yellow red yellow CKMT2 yellow yellow yellow red yellow NKD2 yellow yellow yellow gray yellow ATP6V1C2 yellow yellow yellow red yellow HILPDA yellow gray yellow gray yellow SLC2A12 yellow yellow yellow yellow yellow ZNF93 yellow yellow gray gray yellow FABP6 yellow yellow yellow red yellow PNLIPRP2 yellow yellow green red yellow ZNF681 yellow yellow gray red yellow PPDPF yellow yellow yellow yellow yellow CYB5B yellow yellow yellow yellow yellow CBX5 yellow yellow yellow red yellow REEP1 yellow yellow yellow gray yellow ZBTB10 yellow yellow green yellow yellow TG yellow yellow yellow red yellow ADCY3 yellow yellow gray yellow yellow DIO3OS yellow yellow green yellow yellow LRRC36 yellow yellow yellow gray yellow AGT yellow yellow green gray yellow CYP4F2 yellow yellow yellow yellow yellow CYP4F3 yellow yellow yellow yellow yellow HENMT1 yellow yellow yellow red yellow NUDT7 yellow yellow green red yellow ZC3H12B yellow yellow yellow yellow yellow FREM2 yellow yellow yellow yellow yellow DNAJC6 yellow yellow yellow yellow yellow ESPN yellow yellow green yellow yellow IFNLR1 yellow yellow yellow red yellow ANXA9 yellow yellow yellow yellow yellow ENTPD6 yellow yellow yellow red yellow L3MBTL1 yellow yellow yellow gray yellow ZNF785 yellow yellow yellow yellow yellow SPIN3 yellow yellow yellow yellow yellow MCF2L-AS1 yellow yellow yellow red yellow TDRKH yellow yellow yellow yellow yellow COBLL1 yellow yellow yellow yellow yellow KCNK5 yellow yellow green red yellow PHACTR3 yellow yellow yellow yellow yellow ST6GAL1 yellow gray yellow red yellow MYRIP yellow yellow green red yellow BEND7 yellow yellow yellow red yellow DBI yellow gray yellow red yellow FGFR4 yellow yellow yellow red yellow AGMAT yellow yellow yellow red yellow RAB11FIP4 yellow gray yellow red yellow GNL3L yellow yellow yellow yellow yellow FHDC1 yellow yellow green red yellow PPM1H yellow yellow yellow red yellow EPHB2 yellow yellow green red yellow ZNF703 yellow yellow yellow red yellow NCR3LG1 yellow yellow yellow yellow yellow MIPEP yellow yellow yellow gray yellow SLC7A1 yellow gray yellow gray yellow PDP2 yellow yellow yellow red yellow TFDP2 yellow yellow yellow yellow yellow TUFT1 yellow yellow yellow red yellow FERMT1 yellow yellow yellow red yellow ATP11A yellow gray yellow yellow yellow GTF3A yellow yellow yellow yellow yellow NUFIP1 yellow yellow yellow yellow yellow RFXAP yellow yellow yellow yellow yellow DDX18 yellow gray yellow gray yellow FSD1L yellow yellow yellow red yellow PIN4 yellow yellow yellow gray yellow PUS10 yellow yellow yellow yellow yellow PHOSPHO2 yellow yellow yellow red yellow TMEM192 yellow yellow yellow red yellow MACC1 yellow yellow yellow yellow yellow ARMCX5 yellow yellow yellow yellow yellow OFD1 yellow yellow yellow yellow yellow USP9X yellow yellow yellow yellow yellow CLCN5 yellow yellow yellow yellow yellow EIF2S3 yellow gray yellow red yellow TAB3 yellow yellow yellow yellow yellow EIF1AX yellow gray yellow yellow yellow MED14 yellow yellow yellow red yellow POLA1 yellow gray yellow yellow yellow TXLNG yellow yellow yellow yellow yellow SCML1 yellow yellow yellow yellow yellow FAM122B yellow yellow yellow yellow yellow BRCC3 yellow yellow yellow red yellow THOC2 yellow gray yellow yellow yellow MEST yellow yellow yellow yellow yellow DUS4L yellow yellow yellow yellow yellow NAA38 yellow gray gray gray yellow FAM60A yellow gray yellow red yellow EPB41L5 yellow yellow yellow red yellow ZDHHC23 yellow yellow green red yellow GPSM2 yellow yellow yellow red yellow CDCA7 yellow yellow yellow red yellow NFE2L3 yellow yellow yellow red yellow SRPK1 yellow gray yellow red yellow MYB yellow red green red yellow STRBP yellow yellow yellow red yellow CLDN15 yellow yellow yellow yellow yellow ERP27 yellow yellow yellow red yellow APCDD1 yellow yellow yellow yellow yellow CAB39L yellow yellow yellow gray yellow SYNE4 yellow yellow gray yellow yellow IRF2BP2 yellow gray yellow yellow yellow PTPRO yellow yellow yellow red yellow LRRC2 yellow yellow yellow yellow yellow BCL11A yellow yellow yellow red yellow FOXO3 yellow yellow yellow gray yellow SESN1 yellow yellow yellow yellow yellow DGAT2 yellow yellow yellow yellow yellow COL9A3 yellow yellow yellow gray yellow USP7 yellow yellow yellow yellow yellow C6orf123 yellow yellow yellow yellow yellow LAPTM4B yellow yellow yellow yellow yellow ZFAS1 yellow yellow yellow yellow yellow FER1L4 yellow yellow yellow yellow yellow MAP1LC3A yellow yellow yellow gray yellow CTSA yellow yellow yellow yellow yellow SDC4 yellow yellow yellow yellow yellow GPR56 yellow yellow yellow yellow yellow CACNA1D yellow yellow yellow yellow yellow EPDR1 yellow yellow yellow yellow yellow PROX1 yellow yellow yellow yellow yellow DACH1 yellow yellow yellow red yellow DUSP18 yellow yellow yellow red yellow PTCH1 yellow yellow yellow red yellow RLN2 yellow yellow yellow yellow yellow BCL2L1 yellow yellow yellow gray yellow PRDX5 yellow yellow green red yellow SHANK2 yellow yellow yellow yellow yellow KHDRBS3 yellow yellow yellow yellow yellow GYG2 yellow yellow yellow yellow yellow IL22RA1 yellow yellow yellow yellow yellow PAH yellow yellow yellow yellow yellow DUSP16 yellow yellow green red yellow NANO yellow gray yellow yellow yellow NCOA3 yellow yellow yellow yellow yellow ETV4 yellow yellow yellow yellow yellow SPIRE2 yellow yellow yellow yellow yellow ANO9 yellow yellow yellow yellow yellow ENGASE yellow yellow yellow yellow yellow GAS2 yellow yellow yellow yellow yellow PIPOX yellow yellow yellow yellow yellow CYP2B6 yellow yellow green red yellow ELMO2 yellow yellow yellow yellow yellow NKD1 yellow yellow yellow yellow yellow DPEP1 yellow yellow yellow red yellow ZNRF3 yellow yellow yellow red yellow C7orf13 yellow yellow yellow yellow yellow SLC7A6 yellow yellow yellow yellow yellow TLE2 yellow yellow yellow yellow yellow EMILIN3 yellow yellow yellow yellow yellow EPB41L1 yellow yellow yellow yellow yellow MAP7D2 yellow yellow yellow yellow yellow REPIN1 yellow yellow yellow red yellow PM20D2 yellow yellow yellow yellow yellow CRCP yellow gray yellow yellow yellow GGH yellow yellow yellow red yellow ABAT yellow yellow yellow yellow yellow C11orf95 yellow yellow yellow yellow yellow ZNF217 yellow yellow yellow yellow yellow CHN2 yellow yellow yellow yellow yellow GSE1 yellow yellow yellow yellow yellow RBP2 yellow yellow yellow yellow yellow SHROOM2 yellow yellow yellow yellow yellow AKAP1 yellow yellow yellow yellow yellow STOX1 yellow yellow yellow yellow yellow SLC19A3 yellow yellow yellow gray yellow ACSL6 yellow yellow yellow yellow yellow CASK yellow gray yellow yellow yellow CTPS2 yellow yellow yellow yellow yellow HSPH1 yellow yellow yellow yellow yellow GTF2F2 yellow gray yellow yellow yellow NDFIP2 yellow yellow yellow yellow yellow TMTC4 yellow yellow yellow yellow yellow UCHL3 yellow yellow yellow gray yellow SPATA13 yellow yellow yellow yellow yellow NEK3 yellow yellow yellow yellow yellow PROSER1 yellow yellow yellow yellow yellow WDR35 yellow yellow yellow yellow yellow ZNF514 yellow yellow yellow yellow yellow CBFA2T2 yellow yellow yellow yellow yellow ZMYND8 yellow yellow yellow yellow yellow CHD6 yello yellow yello yellow yello PABPC1L yello yellow yello yellow yello RAB22A yello yellow yello yellow yello LINC00657 yello yellow yello yellow yello RBM39 yello yellow yello yellow yello ARFGEF2 yello yellow yello yellow yello PCMTD2 yello yellow yello yellow yello STX16 yello gray yello yellow yello EREG yello yellow yello yellow yello GGT7 yello yellow yello yellow yello PARD6B yello yellow yello yellow yello TOP1 yello gray yello yellow yello YAE1D1 yello yellow yello yellow yello MYC yello yellow yello yellow yello TNNC2 yello yellow yello yellow yello CEL yello yellow yello yellow yello CELP yello yellow yello yellow yello ZDHHC9 yello yellow yello yellow yello HUNK yello yellow yello red yello AXIN2 yello yellow yello red yello ASCL2 yello yellow yello red yello RNF43 yello yellow yello red yello QPRT yello yellow yello yellow yello TSPAN6 yello yellow gree red yello VAV3 yello yellow gree red yello NEU1 yello yellow yello yellow yello C8orf33 yello yellow yello yellow yello PLA2G12B yello yellow yello yellow yello GTF2IRD1 yello yellow yello yellow yello POFUT1 yello yellow yello yellow yello KRT23 yello yellow yello yellow yello ARID3A yello yellow yello yellow yello CABLES2 yello yellow yello yellow yello SERINC3 yello yellow yello yellow yello GNG4 yello yellow yello yellow yello GPR143 yello yellow yello yellow yello SPATA2 yello yellow yello yellow yello MOCS3 yello gray yello yellow yello NDRG3 yello gray yello yellow yello TTPAL yello yellow yello yellow yello ATP9A yello yellow yello yellow yello CHMP4B yello yellow yello yellow yello COMMD7 yello yellow yello yellow yello EIF2S2 yello yellow yello yellow yello TCFL5 yello yellow yello yellow yello DSN1 yello gray yello gray yello SLMO2 yello yellow yello yellow yello CSE1L yellow yellow yellow yellow yellow DPM1 yellow yellow yellow yellow yellow PFDN4 yellow yellow yellow yellow yellow ACOT8 yellow yellow yellow yellow yellow DHX35 yellow yellow yellow yellow yellow PXMP4 yellow yellow yellow yellow yellow AHCY yellow yellow yellow yellow yellow MRGBP yellow gray yellow gray yellow AURKA yellow gray yellow gray yellow TPX2 yellow gray yellow gray yellow UBE2C yellow gray yellow gray yellow SLC5A6 yellow yellow yellow yellow yellow FITM2 yellow yellow yellow yellow yellow TM9SF4 yellow yellow yellow yellow yellow UCKL1 yellow yellow yellow yellow yellow DNTTIP1 yellow yellow yellow yellow yellow RNF114 yellow yellow yellow yellow yellow GSS yellow yellow yellow yellow yellow SCAND1 yellow yellow yellow yellow yellow TP53RK yellow yellow yellow yellow yellow ADRM1 yellow yellow yellow yellow yellow TOMM34 yellow yellow yellow yellow yellow RPS21 yellow yellow yellow yellow yellow CPNE1 yellow yellow yellow yellow yellow ASXL1 yellow yellow yellow yellow yellow ROMO1 yellow yellow yellow yellow yellow RAE1 yellow yellow yellow yellow yellow VAPB yellow yellow yellow yellow yellow ERGIC3 yellow yellow yellow yellow yellow PLAGL2 yellow yellow yellow yellow yellow DYNLRB1 yellow yellow yellow yellow yellow TTI1 yellow yellow yellow yellow yellow PRPF6 yellow yellow yellow yellow yellow YTHDF1 yellow yellow yellow yellow yellow DDX27 yellow yellow yellow yellow yellow EIF6 yellow yellow yellow yellow yellow PIGU yellow yellow yellow yellow yellow NELFCD yellow yellow yellow yellow yellow CTNNBL1 yellow yellow yellow yellow yellow PSMA7 yellow yellow yellow yellow yellow KIF3B yellow yellow yellow yellow yellow FAM217B yellow yellow yellow yellow yellow PPP1R3D yellow yellow yellow yellow yellow DIDO1 yellow yellow yellow yellow yellow STK4 yellow yellow yellow yellow yellow YWHAB yellow yellow yellow yellow yellow LPAR3 red gray gray gray red PF4 red gray gray red red SDC1 red gray green red red TMEM2 red gray red red red IGFBP2 red gray green gray red FOXA1 red gray gray gray red RRN3P1 red gray gray red red CEACAM8 red gray green red red GIF red magenta green red red C1orf116 red magenta green red red RELL1 red gray gray red red UBXN10 red gray gray red red ZFP3 red gray green red red SLC35G1 red gray gray gray red HES1 red gray green gray red FAIM2 red gray gray gray red KCNN4 red gray green red red GAL3ST1 red red green red red METTL7B red red green red red SLC9A3R1 red gray gray red red COBL red gray gray gray red LTK red gray gray gray red ENTPD2 red gray green gray red MAP3K13 red gray green gray red TM4SF20 red gray gray red red CCL24 red gray gray red red CHST4 red gray gray gray red EGF red red gray gray red DEFA5 red greenyellow green red red DEFA6 red greenyellow green red red LYPD6B red gray gray gray red DNAJC12 red gray gray gray red PCSK1 red magenta gray gray red NTN4 red greenyellow gray gray red SMAD9 red gray green gray red GPR128 red gray gray gray red PCCA red magenta green red red COL4A5 red greenyellow green gray red CASZ1 red gray red gray red OTC red gray green gray red REG3A red magenta red gray red REG1P red magenta red gray red REG1A red magenta red gray red REG1B red magenta red gray red CAPN12 red gray red red red C21orf33 red gray gray red red LONRF3 red magenta red gray red PRKAG2-AS1 red gray gray gray red SOSTDC1 red gray gray red red RNF183 red magenta red gray red ZC3H12D red gray gray red red HR red gray gray red red TMED6 red red gray red red PCDH20 red gray green gray red AKR1C3 red gray green red red TSPAN7 red greenyellow green gray red CYCS red gray green gray red C4BPA red red red red red TM4SF5 red red green red red TLE1 red magenta red gray red NDNF red red green gray red ACOT13 red red green red red ACAA2 red red gray red red MKNK2 red gray gray red red C1orf226 red magenta gray red red NEO1 red red green red red MTMR11 red red green red red PVRL3 red red green red red DEFB1 red gray gray gray red SLC16A5 red gray green red red ARHGAP27 red gray gray red red ERBB2 red gray green red red RAPGEFL1 red red green red red PROM1 red gray gray red red DHRS1 red gray red gray red NOXO1 red red green gray red C2orf82 red red green red red SMAGP red red green red red TMEM141 red red green gray red ABHD14B red gray green red red BAIAP2L2 red gray green red red STARD10 red gray green red red ASL red red green red red CLN3 red gray green red red FAAH red gray green red red NOS2 red gray gray gray red TRIM15 red gray gray gray red KCNE3 red gray green red red SCIN red magenta green red red GSTA1 red gray green gray red COL17A1 red gray green red red NPY6R red gray gray gray red NQO1 red red green red red CAPN8 red red green gray red MXD1 red gray green gray red TRIM31 red red green red red ALDH6A1 red gray red red red CYP2C18 red gray red gray red CYP2C9 red gray red gray red WFDC2 red red green gray red ANXA13 red magenta green red red C1orf115 red red gray red red PRSS16 red gray red gray red GDA red magenta red gray red ADORA2B red gray red gray red APOBEC1 red red green red red MAP2K6 red gray green red red EMP2 red red green red red TRHDE red red green red red VWA5A red red green gray red PPARGC1A red gray green red red UGT2A3 red red green red red CNTN3 red greenyellow green gray red HAPLN1 red gray gray gray red BMP5 red greenyellow gray gray red FAM150B red greenyellow green gray red ITGA8 red greenyellow gray gray red ADAMDEC1 red greenyellow gray gray red DNASE1L3 red greenyellow gray gray red METTL7A red gray green gray red SEPP1 red greenyellow green gray red LPHN3 red greenyellow green red red BBIP1 red greenyellow green red red PRKACB red greenyellow green gray red PCSK6 red gray red red red SLPI red magenta red gray red L1TD1 red magenta red gray red GNA14 red magenta red gray red NEDD9 red magenta red gray red TPK1 red gray gray gray red GAREM red magenta gray gray red CNGA1 red red green red red ADH6 red red green red red CMBL red magenta red red red ATP1B1 red gray red gray red NPDC1 red magenta red gray red COL9A2 red red red gray red TMEM45B red red gray red red BLNK red magenta red gray red TMEM92 red magenta red gray red BACE2 red magenta red red red RASAL1 red magenta red gray red LINC00668 red red green gray red AXDND1 red red green red red COL4A6 red greenyellow green gray red SLC6A14 red magenta red gray red IRF6 red gray green red red ASS1 red magenta gray gray red GSDMB red gray gray gray red SGPP2 red gray gray gray red RORC red red red red red 3-Mar red magenta red gray red CLDN23 red greenyellow green red red CDHR2 red gray green red red MALL red red green gray red LRG1 red magenta red gray red PTPRF red gray green red red SERINC2 red red green red red WNT4 red red gray red red S100P red magenta red gray red OVOL2 red gray green red red TMEM37 red greenyellow green gray red TUBAL3 red red green red red EPHX2 red red red red red GBA3 red gray green gray red NR1H4 red gray green gray red TMEM254 red gray green gray red HOXB13 red gray red red red C1orf21 red magenta red gray red ALDOB red red green gray red LGALS2 red gray green gray red PDCD6IP red gray gray red red ZG16B red red red gray red TMPRSS4 red red green red red SLC5A1 red red green red red SLC44A3 red red green red red PLEKHA6 red red green gray red STAP2 red red green red red MAOA red red green red red ANKS4B red red green red red NRARP red red green red red BDH1 red red green red red HADH red red green red red PPP1R1B red red green red red FUT3 red gray green red red FUT6 red red green red red TMC4 red red green red red BCL2L14 red red green red red ATP2C2 red red green red red TTC39A red red green red red FZD5 red red green red red CORO2A red red green red red CALML4 red red green red red PIP5K1B red red green red red CLRN3 red red green red red MUC13 red red red red red PRR15L red red green red red HDHD3 red red green red red USH1C red red green red red DMBT1 red magenta red red red BCL2L15 red red green red red LCN2 red red red gray red PDZK1IP1 red red red red red HGD red red red red red HMGN2P46 red magenta green red red MMP28 red magenta gray red red ALDH1L1 red gray red gray red DQX1 red red gray red red TMEM171 red gray red gray red FUT2 red red red red red ACSM3 red red green red red NDRG2 red red green gray red GOLM1 red red red red red SYTL5 red red green red red TRPM4 red red green red red PI3 red magenta red gray red CRYM red red green red red CLMN red red green red red PRSS12 red magenta gray red red C1orf210 red gray gray red red ABCC3 red red gray red red PIGR red red red gray red SLC28A2 red red green gray red BMP2 red magenta red gray red TRPA1 red greenyellow green red red NUDT16 red magenta red red red SCNN1A red red red red red TMEM246 red magenta red gray red SLITRK6 red magenta red gray red CATSPERB red magenta red gray red AMN red magenta gray gray red FRMD3 red magenta gray gray red TSPAN3 red gray red red red CHP1 red gray red gray red HSD17B2 red red gray gray red GCNT3 red magenta red gray red LIPH red magenta gray gray red PPP1R36 red red red red red GALNT12 red magenta red red red KIAA1324 red magenta red red red C9orf152 red red green red red FOXA3 red red red red red MUC5B red magenta red gray red TCEA3 red magenta green red red RETNLB red red green red red SLC9A2 red red green red red C2orf72 red magenta red gray red PTGER4 red red red gray red PDXDC1 red gray red red red PLD1 red red red gray red SHROOM3 red magenta red red red TSPAN13 red magenta red gray red IQGAP2 red magenta red gray red DSC2 red gray red red red CAMK2D red gray gray gray red ATP8A1 red magenta red gray red SLC2A13 red magenta red red red PAPSS2 red magenta red red red LGR4 red magenta red red red TNFRSF11A red magenta red gray red STYK1 red magenta red gray red CCDC68 red magenta gray gray red CASP7 red magenta red gray red LIMA1 red red red gray red ABHD3 red gray red gray red GSKIP red magenta red gray red TC2N red magenta gray gray red SMIM14 red magenta red gray red LAMA1 red magenta gray red red ASRGL1 red magenta red gray red TFF3 red red red red red GNE red magenta red gray red RNASE4 red magenta red gray red TFF1 red magenta red gray red PTGER2 red magenta red gray red RHBDL2 red magenta red red red MB red magenta red gray red RAP1GAP red magenta red gray red AGR2 red magenta red gray red AGR3 red magenta red gray red MRAP2 red magenta red red red ANG red magenta red gray red ZBTB7C red magenta red gray red ST3GAL4 red magenta red gray red KLK1 red magenta green red red CHST5 red magenta red red red FFAR4 red magenta red gray red KLF4 red gray red gray red ATP2A3 red gray red red red TMEM61 red magenta red gray red ATOH1 red magenta red red red LINC00261 red magenta red gray red BCAS1 red magenta red red red SPDEF red magenta red gray red CAPN9 red magenta red gray red ST6GALNAC1 red magenta red red red ITLN1 red magenta red red red REG4 red magenta red gray red HEPACAM2 red magenta red red red B3GNT6 red magenta red gray red SPINK4 red magenta red gray red FCGBP red magenta red gray red MUC2 red magenta red gray red CREB3L1 red magenta red gray red RAB26 red magenta red gray red SIDT1 red magenta red gray red MLPH red magenta red gray red RAB27B red magenta gray gray red GDPD3 red gray green red red CES2 red red green red red NR5A2 red red green red red PARM1 red gray red red red DHRS11 red gray green red red CWH43 red red green red red GNA11 red gray green gray red TST red red gray red red HRCT1 red red green red red PKIB red greenyellow green gray red SMPDL3A red gray red gray red SMPD3 red red green red red FMO5 red red green red red INSL5 red gray gray gray red DENND2A red gray green red red FAM162A red red green red red SRI red gray green red red SLC17A4 red red green red red PDE9A red red green red red MGLL red greenyellow green red red ACVRL1 red greenyellow green red red RNF186 red red green red red DUOX2 red red green re red DUOXA2 red red green re red FXYD3 red gray red re red LGALS3 red gray green re red GGT6 red red green re red MYO1A red red green re red CASP5 red red red re red UGT2B15 red red green re red UGT2B17 red greenyellow green re red FAM132A red red green re red EDN3 red greenyellow green re red TTC22 red red green re red PTPRH red red red re red TMEM54 red red red re red CDC42EP5 red red red re red ETHE1 red red red re red LRRC66 red red green re red CA12 red magenta red re red CDHR5 red red green re red BTNL8 red red gray re red CHP2 red red green re red HHLA2 red red green re red SLC51B red red green re red PLCE1 red red green re red HSD11B2 red red green re red VIPR1 red red green re red FAM3D red red green re red CAPN5 red red green re red C4orf19 red red red re red SLC44A4 red red green re red LINC00675 red red green re red GPA33 red red green re red LGALS4 red red green re red PADI2 red greenyellow green re red MOGAT2 red red green re red CEACAM7 red red green re red NXPE1 red red green re red NXPE4 red red green re red ENTPD5 red red green re red SULT1B1 red red green re red XDH red red red re red CES3 red red red re red AHCYL2 red gray red re red AKR1B10 red red green re red SIAE red gray red re red ATP8B1 red gray red re red RBM47 red gray red re red SCGB2A1 red magenta red gray red CHGA red greenyellow green gray red SCARA5 red greenyellow green gray red MFSD4 red red green red red PLAC8 red magenta red gray red AQP8 red red green red red B3GNT7 red gray green gray red GCG red greenyellow green gray red ADH1C red red green red red ABCC13 red red green red red DHRS9 red gray green gray red ADTRP red red green gray red ITM2C red gray red red red BEST2 red red green red red MUC4 red magenta red gray red TSPAN1 red red red red red NR3C2 red magenta red red red CLCA1 red red red red red CCL28 red red red red red VSIG2 red red red red red SPINK5 red red green gray red C2orf88 red greenyellow green red red SI red red green gray red SCNN1B red gray green red red CLDN8 red gray green gray red CD177 red gray green gray red GUCA2B red red green gray red CLCA4 red red green red red MS4A12 red red green red red CA1 red red green gray red CA4 red red green gray red ZG16 red red green red red CA2 red gray red gray red SLC4A4 red magenta red gray red MGST1 red gray gray gray red GATA6 red gray gray red red PPARGC1B red gray gray red red KBTBD11 red red gray red red PLEKHH1 red red gray red red SH3RF2 red red red red red SLC39A8 red magenta red red red UQCRC2 red gray red red red DNAJC22 red red green gray red NEDD4L red gray red red red C3orf52 red magenta red gray red ARHGAP32 red gray red red red ELL3 red magenta gray gray red LRRC16A red gray gray gray red EHHADH red gray green red red TRIM36 red gray red red red MYO5C red gray gray gray red TTC19 red gray red gray red HK2 red gray red gray red BCL10 red gray red red red F2RL1 red red red gray red ELOVL6 red gray gray gray red FRK red gray gray gray red MCTP2 red gray red gray red SLC27A2 red gray red gray red AFG3L2 red magenta gray gray red PKP2 red gray red gray red UGT8 red gray red gray red ADH1A2 black black black black SBSPON turquoise turquoise gray turquoise MSX2 turquoise turquoise gray gray TBX3 brown green gray gray KREMEN1 brown green gray gray DKK4 turquoise gray gray turquoise SP5 brown gray gray gray AVPR1A black black gray black FGB turquoise gray gray gray CD99P1 turquoise gray gray turquoise ONECUT2 turquoise gray gray gray AIM1L turquoise gray gray turquoise IQCE black gray gray gray NOL3 turquoise gray gray turquoise SPNS2 black black black gray DUSP27 turquoise gray gray turquoise ZNF718 black gray black black FOLR1 turquoise turquoise gray gray SOX1 turquoise gray gray turquoise LINC00476 turquoise gray turquoise gray ADH4 turquoise gray gray turquoise PTPRN2 turquoise gray turquoise gray SOX6 turquoise gray turquoise turquoise EML6 turquoise turquoise gray gray APH1A black gray gray gray REEP6 black gray gray gray AGFG2 brown green gray gray AMFR black gray gray gray HMBOX1 turquoise gray gray turquoise GRIN2D brown gray gray gray KDELR1 turquoise gray gray turquoise LPHN1 turquoise gray gray turquoise NSMF brown gray gray brown SH3GLB2 black gray black gray ARHGDIA turquoise gray gray turquoise MAZ brown green gray brown GNB2 black gray gray gray YKT6 turquoise gray gray gray OGDH turquoise gray gray gray URGCP turquoise gray gray gray GABRB1 turquoise turquoise turquoise turquoise NFIA turquoise gray gray gray ECHDC2 turquoise gray gray turquoise RHOU turquoise gray gray turquoise CPA6 turquoise turquoise gray gray MLXIP turquoise gray gray turquoise RERE turquoise gray turquoise turquoise EP400 green gray yellow yellow SPEN turquoise gray gray turquoise SRRM2 turquoise gray gray turquoise ARMCX4 turquoise turquoise gray gray PON3 turquoise gray turquoise gray CLGN turquoise turquoise gray turquoise SHC3 turquoise turquoise gray turquoise CA9 black gray gray gray WISP3 turquoise gray gray turquoise NMU turquoise gray turquoise gray MALAT1 turquoise gray gray turquoise DAPP1 black black black black GTSE1 brown brown gray brown AKR1C4 turquoise gray gray gray MIRLET7DHG turquoise turquoise gray turquoise C12orf56 turquoise gray turquoise gray PEX6 turquoise gray turquoise gray MAGEA11 turquoise gray gray turquoise NOS3 turquoise gray turquoise turquoise THSD4 turquoise gray gray turquoise MCOLN2 black black black gray SPAG16 turquoise turquoise gray turquoise PPP2R2C turquoise gray gray gray WFS1 turquoise gray turquoise gray TNFSF15 black gray gray gray AGA black gray gray gray ABCA12 black black gray gray WDR72 turquoise gray turquoise gray IL17A turquoise gray gray gray DPP10 turquoise gray turquoise turquoise MTTP turquoise gray turquoise gray MXI1 turquoise gray turquoise turquoise SLC38A11 turquoise gray gray turquoise DSC3 turquoise turquoise turquoise turquoise HOXB-AS3 turquoise turquoise turquoise turquoise HOXB9 yellow yellow green gray HOXB8 turquoise turquoise gray gray HOXB7 black gray black gray HOXB3 turquoise turquoise turquoise gray HOXB5 turquoise turquoise gray gray HOXB6 black black black gray TESC turquoise gray turquoise turquoise HOXA2 turquoise turquoise gray turquoise HOXA3 turquoise turquoise gray gray HOXA13 yellow gray yellow red HOXA11-AS turquoise gray gray gray HOXA10 turquoise turquoise gray gray HOXA11 turquoise turquoise gray turquoise HOXA5 turquoise turquoise turquoise turquoise HOXA7 turquoise turquoise gray turquoise KCNJ3 black gray black gray MUC17 black gray black gray PRKCA turquoise gray gray turquoise SLC38A5 black gray gray gray TIMP4 turquoise gray gray gray FAM118A turquoise gray gray turquoise GSTM4 black gray black black ERAP1 black black black gray SYNPR turquoise turquoise gray turquoise CHST13 turquoise gray gray gray CYP4V2 black black black gray ZNF334 turquoise turquoise turquoise turquoise WIPI1 turquoise gray gray gray IL33 turquoise turquoise turquoise turquoise NTS turquoise turquoise turquoise turquoise TNIK turquoise gray gray gray SPAG4 turquoise gray turquoise turquoise CTBP1 turquoise gray gray turquoise CLDN10 turquoise gray turquoise turquoise ORM1 turquoise gray turquoise gray GPR37 turquoise gray gray turquoise CTTN black black black gray ITGB8 turquoise turquoise gray turquoise PTGR1 black gray gray gray SCD5 turquoise turquoise gray turquoise TRIM4 turquoise gray turquoise turquoise NUCKS1 turquoise gray gray gray ZC3HAV1 turquoise gray gray gray EGFR turquoise gray gray gray SRGAP1 turquoise gray gray gray SALL1 turquoise gray gray gray GRB14 black gray gray gray LGSN turquoise gray turquoise turquoise GLDN black gray black gray GPR27 black gray gray gray ATHL1 turquoise turquoise gray turquoise ALDH1B1 turquoise gray gray gray UBE4B turquoise gray turquoise turquoise C6orf141 black gray gray gray CACNB2 turquoise gray gray turquoise PRUNE2 turquoise turquoise gray turquoise KCNQ1OT1 turquoise turquoise turquoise turquoise PID1 turquoise gray gray turquoise RAB32 turquoise gray gray turquoise MTSS1 turquoise turquoise turquoise turquoise IER3 turquoise gray turquoise turquoise LRRN1 turquoise gray turquoise turquoise CELSR1 turquoise turquoise gray turquoise TMEM178B turquoise gray gray gray MAP2K7 black gray black gray KCNJ2 black black black black RNF39 turquoise gray turquoise turquoise LGR6 turquoise turquoise gray turquoise OAS1 black gray black black JAG2 turquoise turquoise turquoise gray SULT1E1 turquoise gray gray gray TP53 black gray black black KANSL1-AS1 black gray gray gray OLFM1 turquoise turquoise turquoise turquoise WNT11 turquoise gray turquoise gray LRRC41 turquoise gray gray turquoise SHISA6 turquoise gray turquoise turquoise C15orf57 black gray black gray GPR64 turquoise turquoise turquoise turquoise NDRG1 turquoise gray gray turquoise SLC6A8 black gray gray gray PYCARD black gray gray gray C2orf68 turquoise gray gray gray IFITM1 black gray black black NRCAM turquoise gray gray turquoise IL13RA2 turquoise turquoise turquoise turquoise MMP10 black black black black RPS23 turquoise gray gray turquoise MFI2 turquoise turquoise gray turquoise SLC51A black gray gray gray ZBED1 turquoise gray gray turquoise H2AFY2 turquoise gray turquoise turquoise SLCO1B3 black black gray gray FGF20 turquoise gray turquoise turquoise PRR9 turquoise gray gray turquoise KLHL13 turquoise gray turquoise turquoise SEZ6L2 turquoise gray gray turquoise GPM6A turquoise turquoise gray turquoise COL4A3 turquoise gray turquoise turquoise IRX2 turquoise gray gray gray ZDHHC2 turquoise gray gray gray FAM149A black black black gray TNFRSF21 black gray black gray TAPBPL black black black black HOXD13 turquoise gray turquoise turquoise CHURC1 black gray gray gray CCR6 black black gray black ARID1B turquoise gray turquoise turquoise ZC3H12C black black black black TMEM159 black gray black gray SH3KBP1 black black black gray CLIC5 black black black gray GMPR black black black black C11orf70 turquoise turquoise gray turquoise HIST1H2BC black black black black HIST1H1C black black black black HIST1H2BH black black gray gray HIST1H2BK black gray gray gray HIST1H2AC black gray gray gray HIST1H2BD black gray gray gray EMC3 black gray gray black MIDN turquoise gray turquoise turquoise TMPRSS3 black black black black TRIM29 turquoise turquoise turquoise turquoise PXN turquoise gray gray turquoise GJB3 black gray gray gray EPHA2 black gray black gray SFN black gray black gray VASP turquoise gray gray gray GPRC5A black gray gray gray S100A6 black gray black gray C19orf33 black gray gray gray CLTB black gray gray gray MINK1 black black black black GABRP black black black gray SLC28A3 black magenta black gray SYT13 black magenta black black RIMS3 black magenta gray gray DNAJA4 black gray black gray PPP1R9A green green gray gray MIPOL1 black black gray gray KANSL1L turquoise gray turquoise turquoise ZNF204P black magenta black black DUSP6 black black gray gray CPS1 black magenta black gray BTNL9 black magenta black black ANKRD37 black black black black MIR210HG black black black gray RPH3AL red magenta red gray VPS53 black magenta black gray RAP1GAP2 black magenta black gray ECI2 black black gray black AK1 black black black gray TSPAN15 black gray gray black SLC50A1 black gray gray gray CHCHD10 red gray gray gray GOT1 brown brown gray brown TSTA3 brown gray gray brown DEGS2 red magenta red gray IMPA2 red magenta red red GMDS red gray red gray ACPP brown gray gray brown RSPH1 brown gray gray brown FGFBP1 red gray red gray GLRX black black gray black CLDN18 black black black black SLC16A14 black black black black NXF3 black magenta gray gray SLC25A37 black gray black gray ME1 black magenta gray gray SSTR1 brown gray gray gray PITPNM3 red magenta red gray GALNT5 black magenta gray gray BAG1 black gray gray gray SLAIN1 black magenta black black ARSJ black magenta black black SLC36A4 black black black black GP2 black magenta black gray SERPINA1 black magenta gray black CKAP4 turquoise gray gray gray RASD1 turquoise gray gray turquoise SLC18A1 red magenta red gray FAM174B turquoise gray gray gray CA8 red magenta red gray AQP3 black magenta gray gray TOX black magenta gray black ISL1 black black black black ARX black magenta black black SEMG1 black magenta black gray ANXA10 black black black gray PLA2G2A black magenta black black AGPAT9 black magenta gray black KIAA1211 black black black gray HS3ST1 black magenta black gray VNN1 black black black black F3 black magenta black gray MBOAT1 black gray gray black SLC1A1 black magenta black black PLA2G4A black magenta black black MUC1 black magenta gray gray TCN1 black magenta gray gray KCNK6 black magenta black black KLK11 black black gray gray MUC5AC black magenta black gray S100A14 red magenta red gray SYTL4 black magenta gray gray SERPINB5 black magenta black gray KCNK1 black magenta gray gray C4BPB red magenta red gray CD55 black magenta gray gray SRD5A3 black magenta gray gray RNF125 black magenta black gray SLC17A5 black magenta gray gray IL1R2 black magenta gray gray CTSE black magenta gray gray FAM46A black magenta black gray PLLP black magenta black gray MYRF black magenta black gray TFF2 black magenta black gray QSOX1 black gray gray gray KDELR3 black magenta gray gray SEC24D black magenta black black CRIP1 black magenta black gray TFAP2A black magenta black gray SYTL1 black magenta black gray SDR16C5 black magenta gray gray DUSP4 black magenta black gray S100A16 black magenta black gray INPP1 black magenta gray gray TRIM7 black magenta gray gray ASPHD2 black magenta black gray HPSE black magenta black gray EGLN3 black magenta gray gray SERPINB1 black magenta gray gray IFNGR1 black gray black black IL18 black magenta black gray IVNS1ABP black magenta black black RPS27L black magenta black black SPATA18 black black black black KITLG turquoise gray gray gray SEC22B black gray black black FRMD4B black magenta gray gray SNAP23 black gray gray gray MTUS1 black magenta black gray RNF145 black magenta gray gray STS black magenta gray gray ENOSF1 brown brown gray brown KIAA0895 brown gray gray brown DYX1C1 black black black black OXCT1 black magenta black black TEX9 black magenta black gray FBXO16 brown gray gray brown PPAPDC1B black magenta black black MOCOS brown gray gray brown ME2 black gray black gray ZNF232 black gray black gray NUDT6 black magenta black gray SPTLC2 black gray black gray ARF6 black gray gray gray FUT8 black gray black gray SMEK1 black gray black gray CYB5D1 brown brown gray brown GLOD4 brown green gray brown SMAD2 black gray black gray SMAD4 black black black black SS18 black gray black gray SLC18B1 black magenta black gray GPR126 black gray black gray MBP black black black gray ZCCHC2 black black black gray INO80C black gray black gray FECH black magenta black gray PIAS2 black gray gray gray HSPA4L brown brown gray brown RPL22L1 black gray black gray CAPN6 turquoise turquoise turquoise turquoise ZNF844 turquoise turquoise turquoise turquoise TMEM99 turquoise turquoise gray turquoise MYEOV black black black gray TMEM150C turquoise turquoise gray turquoise DPP4 black black black black CYP27A1 turquoise gray gray turquoise PRSS21 black black black black KIF1C turquoise gray gray gray SERPIND1 turquoise gray gray turquoise BEX5 black black black gray TKTL1 turquoise gray gray gray ALPK3 turquoise turquoise turquoise turquoise CFB black black black black SYT17 turquoise gray gray turquoise TPPP black magenta black gray EFNB2 turquoise gray turquoise gray EPHB1 turquoise turquoise turquoise turquoise MAEL turquoise gray turquoise turquoise ZNF862 turquoise turquoise turquoise gray PRRC2B turquoise gray gray gray CELF2 turquoise gray turquoise turquoise SLC39A14 black gray black gray MCOLN3 turquoise gray turquoise turquoise CLN8 black gray gray gray C8orf4 turquoise gray turquoise turquoise TBXAS1 black black gray gray SULT1C4 turquoise gray gray gray MME turquoise turquoise turquoise turquoise ZIC2 black magenta black gray APOA2 turquoise gray gray gray TPPP3 turquoise gray gray turquoise SERP2 turquoise gray turquoise turquoise ARHGEF9 turquoise gray gray turquoise CNKSR3 turquoise gray turquoise turquoise PTGDR black black black black TSHZ1 turquoise turquoise turquoise turquoise TCAM1P turquoise gray gray gray IRX3 black black black gray C2 black black black gray MVB12A black black black gray RRAS2 turquoise gray turquoise turquoise LGALS9 black black black black ASPHD1 black gray black gray GAL turquoise turquoise turquoise turquoise SLC4A11 black black black gray PTPN13 turquoise turquoise gray turquoise MAGEA12 turquoise gray gray turquoise TMEFF2 turquoise gray gray turquoise KLHL29 turquoise gray gray turquoise NOD2 turquoise turquoise turquoise turquoise ACOT4 black gray gray gray MYBL1 black black black gray ZNF43 turquoise turquoise gray turquoise DLL1 turquoise gray gray turquoise FZD10 turquoise turquoise turquoise turquoise WWOX turquoise turquoise gray gray PTPN1 turquoise gray gray turquoise LARP6 turquoise turquoise gray turquoise LDLRAD3 turquoise gray gray turquoise XIST turquoise gray turquoise gray HLTF turquoise turquoise turquoise turquoise DMKN black magenta black black TNNC1 turquoise turquoise turquoise turquoise IL2RG black black gray black TMEM154 black gray gray black TPGS1 black black gray black GPC3 black gray gray black PRKCQ black black black black HP1BP3 turquoise gray turquoise turquoise SYT1 turquoise gray gray turquoise KCNMB4 turquoise turquoise turquoise turquoise NFIB turquoise gray turquoise turquoise RTN3 turquoise gray gray turquoise TSPAN5 turquoise turquoise gray turquoise XCL1 black black black gray TNFSF11 turquoise gray gray turquoise RUFY2 black gray black black FOXD1 black black black gray FREM1 turquoise turquoise gray gray RUNDC3B turquoise turquoise turquoise turquoise ZNF185 turquoise turquoise turquoise gray KIAA0125 black black black black PPL turquoise gray turquoise turquoise LMF1 turquoise gray turquoise turquoise FLRT3 black black black black LUZP1 turquoise turquoise gray turquoise SLC2A1 turquoise turquoise gray turquoise ARPC4 black gray black gray ABHD2 turquoise gray turquoise turquoise HHLA3 black gray black black EDN1 turquoise gray gray turquoise SATB1 turquoise turquoise gray turquoise RAPGEF4 turquoise turquoise turquoise turquoise DDX43 turquoise gray gray gray PSTPIP2 turquoise gray gray turquoise LEMD1 turquoise turquoise gray turquoise PVRL2 turquoise gray gray gray FRMD5 black black gray gray GAD1 black magenta black gray GSTZ1 black gray black gray MPI black gray black black KPNA6 black gray gray gray MOV10 black gray black gray UAP1L1 black gray black black CDK2AP2 black gray black gray LPCAT1 black magenta black gray BSG black gray black gray MIB2 black gray black gray TNFSF9 black gray black gray CBR3 black magenta black black ACIN1 black gray black gray AKT1 black gray black gray CALR black gray black black PFKP black gray black gray P4HB black gray black gray PKM black black black gray CDC42EP1 black gray black gray PFN1 black gray black gray RNF19B black gray black gray GPATCH2 turquoise gray gray turquoise HORMAD1 turquoise gray gray turquoise DSG3 turquoise turquoise turquoise turquoise NPY1R black gray gray gray SIPA1L2 turquoise gray gray turquoise BRD2 turquoise gray gray gray IL27RA black gray black black IRF8 black black black black GALC turquoise turquoise turquoise turquoise TGFA black gray gray gray COCH turquoise gray gray turquoise IQGAP1 turquoise gray gray gray BAMBI turquoise turquoise turquoise turquoise NFYC black gray black gray CYP27B1 black black black black ZNF117 turquoise turquoise turquoise turquoise FAM76A turquoise gray turquoise turquoise NME5 turquoise turquoise turquoise turquoise CPLX1 turquoise turquoise gray turquoise INSM1 black magenta black black MGMT turquoise gray turquoise turquoise INSR turquoise gray gray turquoise ERAP2 black black black black CACHD1 turquoise turquoise turquoise turquoise CD44 black magenta gray black ZNF662 turquoise gray gray turquoise GNAS turquoise gray gray turquoise PTPRR black black black black HFE black gray black black PIWIL1 black magenta black gray CSRNP3 turquoise turquoise turquoise turquoise PKDCC turquoise turquoise turquoise turquoise GPR155 turquoise turquoise gray turquoise SKAP1 black gray black gray IGF1R turquoise gray gray turquoise FBXL16 black magenta black black SOX2 turquoise gray gray gray LAMP1 turquoise gray gray turquoise C10orf11 turquoise gray gray turquoise TNFRSF11B turquoise turquoise turquoise turquoise ROBO2 turquoise gray gray turquoise GSTT1 black black gray black SQSTM1 turquoise gray gray turquoise HPGD black black gray gray AFAP1L1 black gray gray gray MAGEA1 black black black black RBP4 turquoise turquoise turquoise turquoise S100A10 turquoise gray gray gray BMP4 turquoise gray gray turquoise CLN5 black gray gray gray PLEKHA2 turquoise gray gray turquoise TGFBI turquoise turquoise gray turquoise SPAG9 turquoise gray turquoise turquoise MSLN turquoise turquoise turquoise gray HBEGF turquoise gray gray turquoise IGF2BP3 black black black black PCP4 turquoise gray gray turquoise NHS turquoise turquoise turquoise turquoise TACSTD2 turquoise turquoise turquoise turquoise 2-Mar black magenta gray black STXBP1 turquoise gray gray turquoise ZNF655 turquoise gray turquoise turquoise TAGAP black black gray gray ID3 turquoise gray gray turquoise FGF18 turquoise turquoise gray turquoise GJB6 turquoise gray gray gray STEAP2 turquoise gray gray gray JUND turquoise gray gray turquoise SLC14A1 turquoise turquoise turquoise turquoise NPTX2 turquoise turquoise turquoise turquoise IGFBP1 turquoise turquoise turquoise turquoise F2RL2 turquoise gray gray turquoise BTBD11 turquoise turquoise turquoise turquoise GOLGA8A turquoise gray turquoise turquoise DNM3 turquoise turquoise gray turquoise KIF26A turquoise gray turquoise turquoise BTG2 turquoise gray gray turquoise CRD16 black black black black CASP1 black black black black NFATC2 turquoise turquoise gray turquoise KIAA1324L turquoise gray turquoise turquoise SORBS2 turquoise turquoise turquoise turquoise KLHL3 turquoise gray gray turquoise GSTM3 turquoise turquoise turquoise turquoise ZNF518B turquoise gray gray turquoise RASSF3 turquoise gray turquoise turquoise APLP2 turquoise gray turquoise turquoise NLRP2 turquoise turquoise gray turquoise SLFN13 black black black black NUB1 black black black black GABRB3 turquoise gray gray turquoise TTC9 turquoise turquoise gray turquoise FAM132B turquoise gray gray turquoise EPHA4 turquoise gray gray gray ZNF697 turquoise turquoise gray turquoise LAMP2 black gray gray gray FGF19 turquoise gray turquoise turquoise TMEM65 turquoise turquoise turquoise turquoise ABCA17P black gray black gray ALDH1A1 turquoise gray gray turquoise TMCO3 black gray black gray TMEM64 black black black gray PCED1A turquoise turquoise gray turquoise TMEM71 turquoise gray turquoise turquoise TFAP2C black black black gray PSD3 turquoise turquoise turquoise turquoise ZNF83 turquoise turquoise turquoise turquoise GATM turquoise turquoise turquoise turquoise FGF9 turquoise turquoise gray turquoise GSTA4 turquoise gray turquoise turquoise HOTAIR black black black gray PDE4A turquoise gray turquoise turquoise WNT5B turquoise gray turquoise turquoise HOXA1 turquoise turquoise gray gray CST3 turquoise gray gray turquoise CHGB turquoise turquoise turquoise turquoise TM4SF4 turquoise gray gray turquoise CD163L1 black black black black IL17RD turquoise turquoise turquoise turquoise SKAP2 turquoise turquoise turquoise gray STEAP1 black black black black ECHDC3 turquoise gray turquoise turquoise PGM2L1 turquoise turquoise turquoise turquoise FKBP11 black black black black ALCAM turquoise gray gray turquoise ZNF347 turquoise turquoise turquoise turquoise DNALI1 turquoise gray turquoise turquoise DDX58 black black black black HCP5 black black black gray RPL39L turquoise gray turquoise turquoise FABP3 turquoise gray turquoise turquoise APOLD1 turquoise gray gray turquoise CDC42 black gray gray gray GBP3 black black black black FBP1 black black gray black EHD4 black gray gray gray KRT80 turquoise turquoise turquoise turquoise OBSCN turquoise turquoise gray turquoise ADRB1 black magenta black gray EMB black black gray gray GZMB black black black black FGFR2 turquoise gray gray turquoise GLCCI1 black black gray black OSR2 black magenta black black ENPP1 turquoise turquoise gray turquoise ADPGK black gray black black CLIC3 turquoise turquoise turquoise turquoise PYROXD2 turquoise gray gray turquoise ZSWIM7 black black black black ABCG2 black gray black gray FRAS1 turquoise gray turquoise turquoise LEPROTL1 black gray black black GALNT10 turquoise turquoise gray turquoise DTNA turquoise turquoise turquoise turquoise TRIP6 turquoise gray turquoise turquoise SMPX turquoise turquoise gray turquoise RHOF black black black gray ADRA2A turquoise turquoise gray turquoise SFTA2 turquoise turquoise gray turquoise SOX8 turquoise gray turquoise turquoise RGS13 black black gray gray ADAM22 turquoise turquoise gray turquoise DOCK11 turquoise turquoise turquoise turquoise KLK6 turquoise turquoise turquoise turquoise AKIRIN2 black gray black gray CDKN1A black black gray gray B4GALT1 black gray black gray ITGA9 turquoise gray gray turquoise CTSS black gray black black KLF13 black black black black TMCC3 black gray black gray RASGEF1A black black black gray LGALS8 black black black black ADAMTS15 turquoise gray gray turquoise HOXD10 turquoise turquoise gray turquoise HOXD11 turquoise turquoise gray turquoise OSBPL8 turquoise turquoise gray turquoise S100A2 turquoise turquoise turquoise turquoise ZNF559 turquoise turquoise turquoise turquoise FRZB turquoise gray gray turquoise CALB1 black black black black GUCY1A2 turquoise turquoise turquoise gray METRN black magenta black gray SLC46A3 turquoise turquoise gray turquoise ARAP3 turquoise turquoise turquoise turquoise MPP1 turquoise gray gray turquoise IGHD black black gray gray GIMAP2 black black black black C3orf70 turquoise turquoise turquoise turquoise PGBD5 turquoise gray gray turquoise ARHGEF6 turquoise gray turquoise turquoise SNCAIP turquoise turquoise turquoise turquoise HBB turquoise gray turquoise gray NT5E black magenta black black INTU turquoise turquoise gray turquoise ENAH turquoise turquoise turquoise turquoise POPDC3 turquoise gray turquoise turquoise ST6GALNAC2 black magenta black gray SSR3 black gray black black SEMA3A turquoise turquoise gray turquoise NRN1 turquoise gray gray turquoise ADAM17 turquoise gray gray turquoise LAMA3 black gray black black HHIP turquoise gray turquoise turquoise IRAK2 black black gray gray HIST2H2BE turquoise turquoise turquoise turquoise MLF1 turquoise turquoise turquoise turquoise NR4A2 black black black gray CRAT turquoise turquoise gray turquoise DDIT4 turquoise gray gray turquoise PLIN2 turquoise turquoise turquoise turquoise PDE10A black gray black black FAM228B turquoise turquoise gray turquoise IBSP turquoise gray gray gray LEPREL1 turquoise turquoise turquoise turquoise THRB turquoise turquoise gray turquoise OPN3 turquoise turquoise gray turquoise EPB41L4A turquoise turquoise turquoise turquoise SNCA turquoise turquoise turquoise turquoise MAN1A1 turquoise gray turquoise turquoise CDA turquoise turquoise turquoise turquoise SERPINE2 turquoise turquoise gray turquoise GLUD2 black gray gray gray MMP1 turquoise gray turquoise gray MMP3 turquoise gray turquoise gray ETV6 black gray black gray KRT6B turquoise turquoise turquoise turquoise COPA turquoise turquoise gray turquoise ZC2HC1A turquoise turquoise gray turquoise SMARCA2 turquoise gray turquoise turquoise PHLDA1 turquoise gray gray turquoise NQO2 black gray black black N4BP2L1 black black gray gray ANKRD29 turquoise turquoise turquoise turquoise DDX60L black black black black TLR3 black black black black TNFSF10 black black black black IK2F2 black black black black PLCL2 black magenta black black RAB27A black magenta black black PCDHB14 turquoise turquoise turquoise turquoise CNTLN black gray black gray FAM13A-AS1 turquoise gray gray gray DEDD turquoise gray turquoise turquoise TNFRSF19 turquoise turquoise turquoise turquoise PRKAA2 turquoise turquoise turquoise turquoise ADSSL1 turquoise gray gray turquoise SRPX2 turquoise turquoise gray turquoise SNX19 turquoise gray turquoise turquoise CCL26 turquoise gray gray gray PELI2 turquoise turquoise turquoise turquoise ITGB1BP1 turquoise gray gray turquoise EFNA5 turquoise gray gray turquoise PRSS23 turquoise gray gray turquoise ELP5 black gray black black MMP7 turquoise turquoise turquoise turquoise VLDLR turquoise turquoise turquoise turquoise TMEM220 black black black black ARRDC4 turquoise turquoise turquoise turquoise INPP5A turquoise gray gray turquoise CTSH turquoise gray gray turquoise P4HA1 black black black black FHOD3 turquoise gray gray turquoise JAG1 turquoise gray gray turquoise TAC1 turquoise gray gray turquoise TJP1 turquoise gray turquoise turquoise TRNP1 black magenta black gray ULBP2 black magenta black gray NELL2 turquoise gray gray turquoise ARHGAP4 black black black black RASAL2 turquoise gray gray turquoise PBX1 turquoise turquoise gray turquoise PARVB turquoise gray gray turquoise SPRR1A black gray black black SPRR1B turquoise gray gray gray SPRR3 turquoise turquoise turquoise gray MBD1 black gray black gray IER5 black magenta black black RBP1 turquoise turquoise turquoise turquoise PTGES turquoise gray turquoise turquoise GALNT18 turquoise gray turquoise turquoise WT1 turquoise turquoise turquoise turquoise ATF3 turquoise gray gray turquoise NR4A1 turquoise gray gray turquoise FOS turquoise gray turquoise turquoise JUNB turquoise gray turquoise turquoise ZFP36 turquoise gray turquoise turquoise STAT3 turquoise gray turquoise turquoise ZNF415 turquoise turquoise turquoise turquoise KRT7 black magenta black gray TAPBP black gray black black KLK10 black black gray gray PPBP turquoise gray turquoise turquoise DYNC1H1 turquoise gray gray turquoise NAGA black gray black gray ZMAT1 turquoise turquoise turquoise turquoise TACC1 turquoise turquoise gray turquoise TBL1X turquoise gray gray turquoise SOD3 turquoise turquoise turquoise turquoise HEXIM1 black black black gray TET1 turquoise turquoise turquoise turquoise PEG10 turquoise gray turquoise turquoise DENND5B black black gray gray DKK1 turquoise turquoise turquoise turquoise ZNF329 turquoise turquoise turquoise turquoise C4orf32 black black black black LYN black black gray gray NRXN3 turquoise turquoise turquoise turquoise EXOC6B turquoise gray turquoise turquoise LOXL1-AS1 turquoise gray gray turquoise WASF3 turquoise turquoise gray turquoise DMD turquoise turquoise gray turquoise SAR1A turquoise gray gray turquoise TGFBR3 turquoise turquoise gray turquoise MUM1 turquoise gray gray turquoise SESTD1 turquoise gray gray turquoise ODAM turquoise turquoise turquoise turquoise OR51E1 turquoise turquoise turquoise turquoise TSHZ2 turquoise turquoise gray turquoise P2RX5 black black black black TMC8 black black black black DPP7 turquoise gray gray gray SPIRE1 turquoise gray turquoise turquoise ERO1LB black black black black PAX5 black black black black LAMC2 turquoise turquoise turquoise turquoise LYZ black black black black FOSL2 black gray gray gray NEFL turquoise turquoise turquoise turquoise ALKBH5 black gray black gray MKX turquoise turquoise turquoise turquoise SLC16A3 black gray black black AFAP1L2 black magenta black black PPP1R3B turquoise gray turquoise turquoise CYP2U1 turquoise turquoise turquoise turquoise LPAR6 turquoise turquoise turquoise turquoise FAM107B black black black black KRT6A turquoise turquoise turquoise turquoise FGF13 turquoise turquoise gray turquoise SCEL turquoise turquoise turquoise turquoise DST turquoise gray turquoise turquoise SALL4 turquoise turquoise gray turquoise TGFBR2 turquoise gray gray turquoise SST turquoise gray turquoise turquoise FNDC3B turquoise gray turquoise turquoise TUBB2B turquoise turquoise turquoise turquoise ZMAT3 turquoise turquoise gray turquoise SERPINA3 turquoise gray turquoise turquoise FLCN black gray black black PFN2 turquoise turquoise turquoise turquoise SLCO3A1 turquoise turquoise turquoise turquoise AHR black magenta gray gray COL27A1 turquoise gray turquoise turquoise SERTAD4 turquoise turquoise turquoise turquoise ANPEP black black black black SOCS1 black black black black F5 black black gray gray SLC16A10 turquoise gray gray turquoise AIF1L black black black gray GABBR1 turquoise gray gray turquoise FGD6 black black black gray ADM black black black black ARRDC3 turquoise turquoise turquoise turquoise RHOD turquoise turquoise turquoise turquoise IL1B black black black black PROK2 black black black black CXCL5 turquoise gray gray turquoise IL24 turquoise gray turquoise turquoise FFAR2 black black black black CDKN2A turquoise turquoise turquoise turquoise LAIR2 black black black black IRF5 turquoise gray turquoise turquoise HSPA12A turquoise turquoise turquoise turquoise LDLRAD4 turquoise gray gray turquoise CXCL6 turquoise gray turquoise gray SLC22A4 turquoise gray turquoise turquoise PROS1 turquoise turquoise turquoise turquoise ARHGAP6 turquoise turquoise turquoise turquoise TYRP1 turquoise gray turquoise turquoise PYGL black black black black PDE3A turquoise turquoise gray turquoise BNIP3 turquoise turquoise turquoise turquoise CDC42BPA turquoise turquoise turquoise turquoise RAB30 turquoise turquoise turquoise turquoise NOTCH2NL turquoise turquoise turquoise turquoise LTF black gray gray black 11-Sep turquoise gray gray turquoise EVA1A turquoise turquoise gray turquoise TM4SF1 turquoise gray turquoise turquoise MRPS21 black black black black WWC3 turquoise turquoise gray turquoise LPL turquoise turquoise turquoise turquoise SLC16A4 turquoise turquoise turquoise turquoise KLF7 turquoise turquoise gray turquoise MICB black magenta black black PDK4 turquoise turquoise turquoise turquoise IGF2 turquoise turquoise turquoise turquoise ADA black black black black PARP8 black black black black FAM127B turquoise gray gray turquoise UCP2 black black black black FAM120C turquoise turquoise gray turquoise C3orf14 turquoise turquoise turquoise turquoise RHOBTB1 turquoise turquoise turquoise turquoise SACS turquoise gray gray turquoise GNA15 black black black black SCG5 turquoise gray turquoise turquoise MAGED1 turquoise turquoise gray turquoise SOCS2 turquoise gray gray turquoise TLR4 turquoise gray turquoise turquoise FKBP5 black gray black gray SAMD3 black black black black IGHG1 black black black black FAM46C black black black black ANKRD36BP2 black black black black KLRB1 black black black black IGJ black black black black FCRL5 black black black black CD79A black black black black PNOC black black gray black IGHM black black black black IGKC black black black black DERL3 black black black black TNFRSF17 black black black black POU2AF1 black black black black GUSBP11 black black black black IGLL3P black black black black MZB1 black black black black PTK7 turquoise gray turquoise turquoise MAP3K6 black magenta black gray PPFIBP1 black gray gray gray COL4A4 turquoise turquoise turquoise turquoise DUSP3 turquoise gray gray turquoise CP black black black gray CERK turquoise turquoise gray turquoise SMOC2 turquoise turquoise turquoise turquoise RARRES1 black black black black SAV1 black black black gray MT1M black black black black MT1E black black black black MT2A black black black black MT1F black black black black MT1H black black black black MT1G black black black black MT1X black black black black SLC2A10 turquoise turquoise turquoise turquoise STMN3 turquoise gray turquoise turquoise SGCB turquoise gray gray turquoise SERPINI1 turquoise turquoise turquoise turquoise RARA turquoise gray gray turquoise CIRBP turquoise gray gray turquoise EVC turquoise turquoise turquoise turquoise GNAI1 turquoise turquoise turquoise turquoise PLA2G16 turquoise turquoise gray turquoise PTGS2 turquoise gray turquoise turquoise CXCL16 black black black black LEPREL4 turquoise gray turquoise turquoise KIT turquoise gray gray turquoise SMIM3 turquoise turquoise gray turquoise TMEM173 black black gray gray SLC9B2 turquoise gray gray turquoise ST20 black gray gray black BMPR1B turquoise turquoise turquoise turquoise KCTD1 black black black gray ZFP37 turquoise turquoise gray turquoise B2M black black black gray PNMA2 black black black gray MMP12 black black black black NOV turquoise turquoise turquoise turquoise CHFR turquoise gray turquoise turquoise SLFN5 turquoise gray gray gray CCDC109B black magenta black black BCL2 black black black black BTN3A2 black black black black IL32 black black black gray STK17B black black black black FAS black magenta black black IL15 black black black black BIRC3 black black black black STK17A black black black black JAK2 black black black black TNFAIP8 black black black black FBXO6 black black black black EPSTI1 black black black black RNF213 black gray black black BATF2 black black black gray PSMB10 black gray black black ISG20 black black black black IFI27 black black black black OASL black black black black SECTM1 black black black black HLA-F black black black black IFIT5 black black black black IFI6 black black black black ETV7 black black black gray APOL6 black black black black RTP4 black black black black DDX60 black black black black SAMD9 black black black black AIM2 black black black black TAP2 black black black black LAMP3 black black black black CXCL11 black black black black NLRC5 black black black black ODF3B black black black black TRIM69 black black black black IRF7 black black black black IFIH1 black black black black MX2 black black black black OAS3 black black black black IFI35 black black black black USP18 black black black black HERC6 black black black black ISG15 black black black black PARP14 black black black black PARP9 black black black black SAMD9L black black black black XAF1 black black black black IFIT1 black black gray gray IFI72 black black black black RSAD2 black black black black IFI44 black black black black CMPK2 black black black black OAS2 black black black black IFI44L black black black black IFIT3 black black black black MX1 black black black black IRF9 black black black black LAP3 black black black black WARS black black black black IRF1 black black black black PSM89 black black black black TAP1 black black black black STAT1 black black black black UBE2L6 black black black black PKIA turquoise turquoise turquoise turquoise SLCO2A1 turquoise gray turquoise turquoise MAST4 turquoise turquoise turquoise turquoise CGNL1 turquoise turquoise turquoise turquoise SLC7A2 turquoise turquoise turquoise turquoise SERPINB2 black black gray gray CTLA4 black black black black MAFF turquoise gray 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black black black black CXCR4 black black black black black GPR34 black gray black black black ARHGDIB black black black black black GBP1 black black black black black CD38 black black black black black BCL2A1 black black black black black JAK3 black black black black black CORO1A black black black black black CD274 black black black black black RASGRP1 black black black black black GATA3 black black black black black APOL3 black black black black black PLEK black black black black black EMR2 black black black black black CD27 black black black black black RASSF4 black black black black black PPP1R16B black black black black black SIGLEC1 black black black black black GNG2 black black black gray black GPR183 black black black black black CYSLTR1 black black black black black GLIPR2 black black black gray black DOCK8 black black black black black RNASE6 black black black black black APOE black black black black black ITGAX black black black black black RAC2 black black black black black 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turquoise turquoise turquoise turquoise turquoise CD99 turquoise turquoise turquoise turquoise turquoise FAM126A turquoise turquoise turquoise turquoise turquoise PPAP2B turquoise turquoise turquoise turquoise turquoise PAM turquoise turquoise turquoise turquoise turquoise NR4A3 turquoise turquoise turquoise turquoise turquoise NEGR1 turquoise turquoise turquoise turquoise turquoise TCF21 turquoise gray turquoise turquoise turquoise PI15 turquoise turquoise turquoise turquoise turquoise FAM20A turquoise gray turquoise turquoise turquoise PENK turquoise turquoise turquoise turquoise turquoise ITGB1 turquoise gray turquoise turquoise turquoise SSH1 turquoise gray gray turquoise turquoise CCDC69 turquoise gray turquoise turquoise turquoise ZSCAN18 turquoise turquoise turquoise turquoise turquoise KCTD12 turquoise turquoise gray turquoise turquoise PTGS1 turquoise turquoise turquoise turquoise turquoise MCC turquoise turquoise turquoise turquoise turquoise SEC14L1 turquoise gray gray gray turquoise SDPR turquoise turquoise turquoise turquoise turquoise SVIL turquoise gray turquoise turquoise turquoise SLC8A1 turquoise gray turquoise turquoise turquoise ARHGAP24 turquoise turquoise turquoise turquoise turquoise PGM5 turquoise turquoise turquoise turquoise turquoise RORA turquoise turquoise turquoise turquoise turquoise WFDC1 turquoise gray turquoise turquoise turquoise ZNF423 turquoise turquoise gray turquoise turquoise HIP1 turquoise turquoise turquoise turquoise turquoise TBC1D9 turquoise turquoise turquoise turquoise turquoise ATXN1 turquoise turquoise turquoise turquoise turquoise GULP1 turquoise turquoise turquoise turquoise turquoise IGF1 turquoise turquoise turquoise turquoise turquoise CADM1 turquoise turquoise turquoise turquoise turquoise TFPI turquoise turquoise turquoise turquoise turquoise FAM198B turquoise turquoise turquoise turquoise turquoise PPAP2A turquoise turquoise turquoise turquoise turquoise FZD8 turquoise turquoise turquoise turquoise turquoise PLA2G5 turquoise turquoise turquoise turquoise turquoise PTN turquoise turquoise turquoise turquoise turquoise PRKG1 turquoise turquoise gray turquoise turquoise RTN1 turquoise turquoise gray turquoise turquoise ABCA1 turquoise turquoise turquoise turquoise turquoise SFRP1 turquoise turquoise turquoise turquoise turquoise FILIP1 turquoise turquoise turquoise turquoise turquoise S100A4 turquoise gray turquoise turquoise turquoise STEAP4 turquoise turquoise turquoise turquoise turquoise RBP7 turquoise turquoise turquoise turquoise turquoise UNC5B turquoise turquoise turquoise turquoise turquoise RBPMS turquoise turquoise gray turquoise turquoise KCNMA1 turquoise turquoise turquoise turquoise turquoise DUSP1 turquoise gray turquoise turquoise turquoise BCHE turquoise turquoise turquoise turquoise turquoise PCSK5 turquoise turquoise turquoise turquoise turquoise LINC00341 turquoise turquoise gray turquoise turquoise ADAMTS6 turquoise turquoise turquoise turquoise turquoise PDGFRA turquoise turquoise turquoise turquoise turquoise CLU turquoise turquoise turquoise turquoise turquoise FLT1 turquoise gray turquoise turquoise turquoise DKK2 turquoise turquoise turquoise turquoise turquoise ATP8B2 turquoise turquoise turquoise gray turquoise DOCK4 turquoise turquoise gray turquoise turquoise HOXB2 turquoise turquoise gray turquoise turquoise GPRASP1 turquoise turquoise gray turquoise turquoise GPM6B turquoise turquoise turquoise turquoise turquoise DEGS1 turquoise turquoise turquoise turquoise turquoise C7 turquoise turquoise gray turquoise turquoise FBXO32 turquoise turquoise turquoise turquoise turquoise MEIS2 turquoise turquoise gray turquoise turquoise DBN1 turquoise turquoise turquoise turquoise turquoise PAPLN turquoise turquoise turquoise turquoise turquoise IGDCC4 turquoise turquoise turquoise turquoise turquoise NOTCH2 turquoise gray turquoise turquoise turquoise SMARCA1 turquoise turquoise turquoise turquoise turquoise SELP turquoise turquoise turquoise turquoise turquoise ADAM19 turquoise turquoise turquoise turquoise turquoise CDO1 turquoise turquoise turquoise turquoise turquoise RCAN2 turquoise gray turquoise turquoise turquoise RHOJ turquoise turquoise turquoise turquoise turquoise MARCO turquoise gray gray gray turquoise RNF144A turquoise turquoise gray turquoise turquoise RUNX2 turquoise turquoise turquoise turquoise turquoise BCL6 turquoise gray gray turquoise turquoise PAPPA turquoise turquoise turquoise turquoise turquoise GPR161 turquoise turquoise turquoise turquoise turquoise KLF2 turquoise turquoise turquoise turquoise turquoise CAV2 turquoise turquoise turquoise turquoise turquoise HEY1 turquoise turquoise turquoise turquoise turquoise FYN turquoise turquoise gray turquoise turquoise FAM13C turquoise turquoise turquoise turquoise turquoise TMTC1 turquoise turquoise turquoise turquoise turquoise PPP1R12B turquoise turquoise turquoise turquoise turquoise PGM5-AS1 turquoise gray turquoise turquoise turquoise OGN turquoise turquoise turquoise turquoise turquoise C2orf40 turquoise turquoise turquoise turquoise turquoise ANGPTL1 turquoise turquoise turquoise turquoise turquoise MAMDC2 turquoise turquoise turquoise turquoise turquoise TCEAL2 turquoise turquoise turquoise turquoise turquoise ATP1A2 turquoise turquoise turquoise turquoise turquoise CHRDL1 turquoise turquoise turquoise turquoise turquoise PDZRN4 turquoise turquoise turquoise turquoise turquoise SCN7A turquoise turquoise turquoise turquoise turquoise FHL1 turquoise turquoise turquoise turquoise turquoise ANK2 turquoise turquoise turquoise turquoise turquoise LMO3 turquoise turquoise turquoise turquoise turquoise C5orf46 turquoise turquoise turquoise turquoise turquoise FAM171B turquoise turquoise turquoise turquoise turquoise SCUBE2 turquoise turquoise turquoise turquoise turquoise GPR133 turquoise turquoise turquoise turquoise turquoise RDX turquoise turquoise turquoise turquoise turquoise CD109 turquoise turquoise turquoise turquoise turquoise ROBO1 turquoise turquoise turquoise turquoise turquoise ADARB1 turquoise turquoise gray turquoise turquoise AGTR1 turquoise turquoise turquoise turquoise turquoise SETBP1 turquoise turquoise turquoise turquoise turquoise LYVE1 turquoise turquoise turquoise turquoise turquoise GPX8 turquoise turquoise turquoise turquoise turquoise CBX6 turquoise turquoise gray turquoise turquoise COL16A1 turquoise turquoise turquoise turquoise turquoise MAN1C1 turquoise turquoise turquoise turquoise turquoise GXYLT2 turquoise turquoise turquoise turquoise turquoise SHISA2 turquoise turquoise turquoise turquoise turquoise GPX3 turquoise turquoise turquoise turquoise turquoise LAMA2 turquoise turquoise turquoise turquoise turquoise ZNF331 turquoise turquoise turquoise turquoise turquoise OLR1 turquoise gray turquoise turquoise turquoise LTBP3 turquoise turquoise turquoise turquoise turquoise GPC1 turquoise turquoise turquoise turquoise turquoise AHNAK2 turquoise turquoise turquoise turquoise turquoise SPP1 turquoise turquoise turquoise turquoise turquoise CNTN4 turquoise turquoise turquoise turquoise turquoise BEX4 turquoise turquoise turquoise turquoise turquoise 6-Sep turquoise gray gray turquoise turquoise RGL1 turquoise turquoise turquoise turquoise turquoise MEG3 turquoise turquoise turquoise turquoise turquoise FABP4 turquoise turquoise turquoise turquoise turquoise EDIL3 turquoise turquoise turquoise turquoise turquoise APOD turquoise turquoise turquoise turquoise turquoise SLC2A3 turquoise gray turquoise turquoise turquoise EMCN turquoise turquoise turquoise turquoise turquoise PRR16 turquoise turquoise turquoise turquoise turquoise SHANK3 turquoise turquoise gray turquoise turquoise PLA2G4C turquoise turquoise turquoise turquoise turquoise CSGALNACT2 turquoise turquoise turquoise turquoise turquoise FGF7 turquoise turquoise turquoise turquoise turquoise TSC22D3 turquoise gray turquoise turquoise turquoise SIRPA turquoise gray turquoise turquoise turquoise CHRDL2 turquoise turquoise turquoise turquoise turquoise TSPAN2 turquoise turquoise turquoise turquoise turquoise OMD turquoise turquoise turquoise turquoise turquoise LINC00312 turquoise turquoise turquoise turquoise turquoise LRRC17 turquoise turquoise turquoise turquoise turquoise NAV3 turquoise turquoise turquoise turquoise turquoise PTGER3 turquoise turquoise turquoise turquoise turquoise ROR2 turquoise turquoise turquoise turquoise turquoise SPHK1 turquoise gray turquoise turquoise turquoise ANKRD6 turquoise turquoise turquoise turquoise turquoise SLFN11 turquoise gray gray turquoise turquoise STAB1 turquoise turquoise gray turquoise turquoise ALPK2 turquoise turquoise turquoise turquoise turquoise PLAT turquoise gray turquoise turquoise turquoise SOX7 turquoise turquoise turquoise turquoise turquoise PPP1R14A turquoise turquoise turquoise turquoise turquoise PLAU turquoise turquoise turquoise turquoise turquoise CSRP2 turquoise turquoise turquoise turquoise turquoise GRP turquoise turquoise turquoise turquoise turquoise BHLHE22 turquoise turquoise turquoise turquoise turquoise EPHA3 turquoise turquoise turquoise turquoise turquoise DIO2 turquoise turquoise turquoise turquoise turquoise SCG2 turquoise turquoise turquoise turquoise turquoise RGS16 turquoise turquoise gray turquoise turquoise ELN turquoise turquoise turquoise turquoise turquoise ELK3 turquoise turquoise turquoise turquoise turquoise CAP2 turquoise turquoise gray turquoise turquoise GPX7 turquoise turquoise turquoise turquoise turquoise PDGFRL turquoise turquoise turquoise turquoise turquoise UCHL1 turquoise turquoise turquoise turquoise turquoise EPYC turquoise turquoise turquoise turquoise turquoise ITGB5 turquoise turquoise turquoise turquoise turquoise GADD45B turquoise gray turquoise turquoise turquoise GLRB turquoise turquoise turquoise turquoise turquoise RGS2 turquoise turquoise turquoise turquoise turquoise DIP2C turquoise turquoise turquoise turquoise turquoise TTC7B turquoise turquoise turquoise turquoise turquoise CCDC88A turquoise gray turquoise turquoise turquoise SAMD4A turquoise turquoise turquoise turquoise turquoise F13A1 turquoise turquoise turquoise turquoise turquoise MEOX2 turquoise turquoise turquoise turquoise turquoise PRELP turquoise turquoise turquoise turquoise turquoise CCL21 turquoise turquoise turquoise turquoise turquoise FST turquoise turquoise turquoise turquoise turquoise CALCRL turquoise turquoise turquoise turquoise turquoise LRRN4CL turquoise turquoise turquoise turquoise turquoise ETS1 turquoise gray turquoise turquoise turquoise ITPRIP turquoise gray turquoise turquoise turquoise SRPX turquoise turquoise turquoise turquoise turquoise CHRNA3 turquoise turquoise turquoise turquoise turquoise PXDC1 turquoise turquoise turquoise turquoise turquoise WNT2 turquoise turquoise turquoise turquoise turquoise SERPINE1 turquoise turquoise turquoise turquoise turquoise PCDH17 turquoise turquoise turquoise turquoise turquoise FAM127A turquoise turquoise turquoise turquoise turquoise DACT1 turquoise turquoise turquoise turquoise turquoise TMEM45A turquoise turquoise turquoise turquoise turquoise NPR3 turquoise turquoise turquoise turquoise turquoise SDK1 turquoise turquoise turquoise turquoise turquoise CYGB turquoise turquoise turquoise turquoise turquoise OLFML2A turquoise gray turquoise turquoise turquoise ARL10 turquoise turquoise turquoise turquoise turquoise HTR2B turquoise turquoise turquoise turquoise turquoise TCEAL3 turquoise turquoise turquoise turquoise turquoise MDFIC turquoise turquoise turquoise turquoise turquoise PALMD turquoise turquoise turquoise turquoise turquoise CILP turquoise turquoise turquoise turquoise turquoise AQP1 turquoise turquoise turquoise turquoise turquoise CXCL12 turquoise turquoise turquoise turquoise turquoise RERG turquoise turquoise turquoise turquoise turquoise TCEA2 turquoise turquoise turquoise turquoise turquoise PBX3 turquoise turquoise turquoise turquoise turquoise GLI3 turquoise turquoise turquoise turquoise turquoise DSEL turquoise turquoise turquoise turquoise turquoise ADAMTS1 turquoise turquoise turquoise turquoise turquoise PTPLAD2 turquoise turquoise turquoise turquoise turquoise ALDH1A3 turquoise turquoise turquoise turquoise turquoise VWF turquoise turquoise turquoise turquoise turquoise ATP2B4 turquoise turquoise turquoise turquoise turquoise CFL2 turquoise turquoise turquoise turquoise turquoise ZNF677 turquoise turquoise turquoise turquoise turquoise RGS4 turquoise turquoise turquoise turquoise turquoise GALNT15 turquoise turquoise turquoise turquoise turquoise SYNE1 turquoise turquoise gray turquoise turquoise CYP1B1 turquoise turquoise turquoise turquoise turquoise TUSC3 turquoise turquoise turquoise turquoise turquoise ZNF532 turquoise turquoise turquoise turquoise turquoise RSPO3 turquoise turquoise turquoise turquoise turquoise NAV1 turquoise turquoise turquoise turquoise turquoise QKI turquoise gray turquoise turquoise turquoise THBS4 turquoise turquoise turquoise turquoise turquoise CALU turquoise gray turquoise turquoise turquoise STOM turquoise turquoise turquoise turquoise turquoise TIMP1 turquoise turquoise turquoise turquoise turquoise RASSF8 turquoise turquoise turquoise turquoise turquoise RGMA turquoise turquoise turquoise turquoise turquoise CPXM2 turquoise turquoise turquoise turquoise turquoise BTBD19 turquoise turquoise turquoise turquoise turquoise ZCCHC24 turquoise turquoise gray turquoise turquoise DENND5A turquoise turquoise turquoise turquoise turquoise ELTD1 turquoise turquoise turquoise turquoise turquoise LPHN2 turquoise turquoise turquoise turquoise turquoise TRPC1 turquoise turquoise turquoise turquoise turquoise TPST1 turquoise turquoise turquoise turquoise turquoise TGFB1 turquoise gray gray turquoise turquoise ISM1 turquoise turquoise turquoise turquoise turquoise INMT turquoise turquoise turquoise turquoise turquoise MMP11 turquoise turquoise turquoise turquoise turquoise LTBP1 turquoise turquoise turquoise turquoise turquoise THBS1 turquoise turquoise turquoise turquoise turquoise HSD17B6 turquoise turquoise turquoise turquoise turquoise NREP turquoise turquoise turquoise turquoise turquoise SSPN turquoise turquoise turquoise turquoise turquoise C10orf10 turquoise turquoise turquoise turquoise turquoise TRPS1 turquoise turquoise turquoise turquoise turquoise KLHL5 turquoise turquoise turquoise turquoise turquoise ADAMTS5 turquoise turquoise turquoise turquoise turquoise SLC24A3 turquoise turquoise turquoise turquoise turquoise LMCD1 turquoise turquoise turquoise turquoise turquoise ANXA6 turquoise turquoise turquoise turquoise turquoise UBE2E2 turquoise turquoise turquoise turquoise turquoise C3 turquoise turquoise turquoise turquoise turquoise MYO5A turquoise gray turquoise turquoise turquoise HSPG2 turquoise turquoise turquoise turquoise turquoise CAV1 turquoise turquoise turquoise turquoise turquoise PNMAL1 turquoise turquoise turquoise turquoise turquoise CLIC4 turquoise turquoise turquoise turquoise turquoise DCHS1 turquoise turquoise turquoise turquoise turquoise KCNJ8 turquoise turquoise turquoise turquoise turquoise EML1 turquoise turquoise turquoise turquoise turquoise TP73-AS1 turquoise turquoise gray turquoise turquoise SMARCD3 turquoise turquoise turquoise turquoise turquoise MEDAG turquoise turquoise turquoise turquoise turquoise CCL2 turquoise gray turquoise turquoise turquoise CLIP4 turquoise turquoise turquoise turquoise turquoise DCLK1 turquoise turquoise turquoise turquoise turquoise ARMCX2 turquoise turquoise turquoise turquoise turquoise CHST15 turquoise gray turquoise turquoise turquoise CALHM2 turquoise turquoise turquoise turquoise turquoise C1QTNF3 turquoise turquoise turquoise turquoise turquoise JAZF1 turquoise turquoise turquoise turquoise turquoise KIF26B turquoise turquoise turquoise turquoise turquoise GNG11 turquoise turquoise turquoise turquoise turquoise ERG turquoise turquoise turquoise turquoise turquoise GJA1 turquoise turquoise turquoise turquoise turquoise RBMS1 turquoise turquoise turquoise turquoise turquoise CPXM1 turquoise turquoise turquoise turquoise turquoise MFAP4 turquoise turquoise turquoise turquoise turquoise ITGBL1 turquoise turquoise turquoise turquoise turquoise MMRN2 turquoise turquoise turquoise turquoise turquoise FZD1 turquoise turquoise turquoise turquoise turquoise LATS2 turquoise turquoise turquoise turquoise turquoise CDH5 turquoise turquoise turquoise turquoise turquoise SGCE turquoise turquoise turquoise turquoise turquoise NID1 turquoise turquoise turquoise turquoise turquoise RBMS3 turquoise turquoise turquoise turquoise turquoise PLXDC2 turquoise turquoise turquoise turquoise turquoise CYBRD1 turquoise turquoise turquoise turquoise turquoise IGFBP3 turquoise turquoise turquoise turquoise turquoise EDNRA turquoise turquoise turquoise turquoise turquoise MN1 turquoise turquoise turquoise turquoise turquoise HS3ST3A1 turquoise turquoise turquoise turquoise turquoise EBF1 turquoise turquoise turquoise turquoise turquoise SERPINH1 turquoise gray turquoise turquoise turquoise GEM turquoise turquoise turquoise turquoise turquoise TNFAIP6 turquoise gray turquoise turquoise turquoise KAL1 turquoise turquoise turquoise turquoise turquoise RAI14 turquoise turquoise turquoise turquoise turquoise HEYL turquoise turquoise turquoise turquoise turquoise CFH turquoise turquoise turquoise turquoise turquoise PALLD turquoise turquoise turquoise turquoise turquoise TNFSF4 turquoise turquoise turquoise turquoise turquoise MXRA7 turquoise turquoise turquoise turquoise turquoise PDLIM4 turquoise turquoise turquoise turquoise turquoise TMEM119 turquoise turquoise turquoise turquoise turquoise NID2 turquoise turquoise turquoise turquoise turquoise MYH10 turquoise turquoise turquoise turquoise turquoise C11orf96 turquoise turquoise turquoise turquoise turquoise MOXD1 turquoise turquoise turquoise turquoise turquoise SGCD turquoise turquoise turquoise turquoise turquoise SYT11 turquoise turquoise turquoise turquoise turquoise DPT turquoise turquoise turquoise turquoise turquoise COL14A1 turquoise turquoise turquoise turquoise turquoise UBE2QL1 turquoise turquoise turquoise turquoise turquoise PCDH7 turquoise turquoise turquoise turquoise turquoise PLXDC1 turquoise turquoise turquoise turquoise turquoise MLLT11 turquoise turquoise turquoise turquoise turquoise CLEC11A turquoise turquoise turquoise turquoise turquoise PPP1R18 turquoise gray gray turquoise turquoise PLEKHO1 turquoise gray gray turquoise turquoise EMP3 turquoise gray gray gray turquoise TSPAN4 turquoise gray turquoise turquoise turquoise FAM19A5 turquoise turquoise turquoise turquoise turquoise LBH turquoise turquoise turquoise turquoise turquoise PRKCDBP turquoise turquoise turquoise turquoise turquoise A2M turquoise turquoise turquoise turquoise turquoise COL8A2 turquoise turquoise turquoise turquoise turquoise IGFBP6 turquoise turquoise turquoise turquoise turquoise SLIT2 turquoise turquoise turquoise turquoise turquoise JAM2 turquoise turquoise turquoise turquoise turquoise PDLIM7 turquoise turquoise turquoise turquoise turquoise GJC1 turquoise turquoise turquoise turquoise turquoise MFAP5 turquoise turquoise turquoise turquoise turquoise CDK14 turquoise turquoise turquoise turquoise turquoise C3orf80 turquoise turquoise turquoise turquoise turquoise PHLDB2 turquoise turquoise turquoise turquoise turquoise SPG20 turquoise turquoise turquoise turquoise turquoise CYS1 turquoise turquoise turquoise turquoise turquoise TIE1 turquoise turquoise turquoise turquoise turquoise CHSY3 turquoise turquoise turquoise turquoise turquoise TNC turquoise turquoise turquoise turquoise turquoise PKD2 turquoise turquoise turquoise turquoise turquoise FAM129A turquoise gray gray turquoise turquoise NEXN turquoise turquoise turquoise turquoise turquoise GAS7 turquoise turquoise turquoise turquoise turquoise ECM2 turquoise turquoise turquoise turquoise turquoise CYR61 turquoise turquoise turquoise turquoise turquoise TCF4 turquoise turquoise turquoise turquoise turquoise HMCN1 turquoise turquoise turquoise turquoise turquoise PTGIS turquoise turquoise turquoise turquoise turquoise AKAP12 turquoise turquoise turquoise turquoise turquoise TMEM47 turquoise turquoise turquoise turquoise turquoise LDB2 turquoise turquoise turquoise turquoise turquoise CLMP turquoise turquoise turquoise turquoise turquoise MPDZ turquoise turquoise turquoise turquoise turquoise CRISPLD1 turquoise turquoise turquoise turquoise turquoise DZIP1 turquoise turquoise turquoise turquoise turquoise PRICKLE1 turquoise turquoise turquoise turquoise turquoise PRICKLE2 turquoise turquoise turquoise turquoise turquoise RECK turquoise turquoise turquoise turquoise turquoise MAP1B turquoise turquoise turquoise turquoise turquoise PPP1R3C turquoise turquoise turquoise turquoise turquoise TCEAL7 turquoise turquoise turquoise turquoise turquoise SYNM turquoise turquoise turquoise turquoise turquoise PDE1A turquoise turquoise turquoise turquoise turquoise PEG3 turquoise turquoise turquoise turquoise turquoise SYNPO2 turquoise turquoise turquoise turquoise turquoise FBLN5 turquoise turquoise turquoise turquoise turquoise NAP1L3 turquoise turquoise turquoise turquoise turquoise SYNC turquoise turquoise turquoise turquoise turquoise ARMCX1 turquoise turquoise turquoise turquoise turquoise SPARCL1 turquoise turquoise turquoise turquoise turquoise KCNMB1 turquoise turquoise turquoise turquoise turquoise CACNA2D1 turquoise turquoise turquoise turquoise turquoise C14orf132 turquoise turquoise turquoise turquoise turquoise MYH11 turquoise turquoise turquoise turquoise turquoise HSPB8 turquoise turquoise turquoise turquoise turquoise DES turquoise turquoise turquoise turquoise turquoise LMOD1 turquoise turquoise turquoise turquoise turquoise ACTG2 turquoise turquoise turquoise turquoise turquoise PLN turquoise turquoise turquoise turquoise turquoise MAB21L2 turquoise turquoise turquoise turquoise turquoise RUNX1T1 turquoise turquoise turquoise turquoise turquoise STON1 turquoise turquoise turquoise turquoise turquoise BOC turquoise turquoise turquoise turquoise turquoise KANK2 turquoise turquoise turquoise turquoise turquoise FXYD6 turquoise turquoise turquoise turquoise turquoise C20orf194 turquoise turquoise turquoise turquoise turquoise PDLIM3 turquoise turquoise turquoise turquoise turquoise MGP turquoise turquoise turquoise turquoise turquoise AOC3 turquoise turquoise turquoise turquoise turquoise AMOTL1 turquoise turquoise turquoise turquoise turquoise TPM2 turquoise turquoise turquoise turquoise turquoise MRVI1 turquoise turquoise turquoise turquoise turquoise TSPYL5 turquoise turquoise turquoise turquoise turquoise FEZ1 turquoise turquoise turquoise turquoise turquoise CNRIP1 turquoise turquoise turquoise turquoise turquoise COX7A1 turquoise turquoise turquoise turquoise turquoise MRGPRF turquoise turquoise turquoise turquoise turquoise MYLK turquoise turquoise turquoise turquoise turquoise CNN1 turquoise turquoise turquoise turquoise turquoise CRYAB turquoise turquoise turquoise turquoise turquoise FILIP1L turquoise turquoise turquoise turquoise turquoise SYNDIG1 turquoise turquoise turquoise turquoise turquoise THBD turquoise turquoise turquoise turquoise turquoise MMP19 turquoise gray turquoise turquoise turquoise DLC1 turquoise turquoise turquoise turquoise turquoise WWTR1 turquoise turquoise turquoise turquoise turquoise FLNA turquoise turquoise turquoise turquoise turquoise CD93 turquoise turquoise turquoise turquoise turquoise MMP14 turquoise turquoise turquoise turquoise turquoise PRKD1 turquoise turquoise turquoise turquoise turquoise NDN turquoise turquoise turquoise turquoise turquoise MAGI2-AS3 turquoise turquoise turquoise turquoise turquoise COMP turquoise turquoise turquoise turquoise turquoise BASP1 turquoise gray turquoise gray turquoise SNAI2 turquoise turquoise turquoise turquoise turquoise RARRES2 turquoise turquoise turquoise turquoise turquoise CTGF turquoise turquoise turquoise turquoise turquoise AKT3 turquoise turquoise turquoise turquoise turquoise IL1R1 turquoise turquoise turquoise turquoise turquoise ST6GALNAC5 turquoise turquoise turquoise turquoise turquoise BICC1 turquoise turquoise turquoise turquoise turquoise KIRREL turquoise turquoise turquoise turquoise turquoise DOK5 turquoise turquoise turquoise turquoise turquoise MSN turquoise gray gray turquoise turquoise FAM101B turquoise turquoise turquoise turquoise turquoise LTBP2 turquoise turquoise turquoise turquoise turquoise FBLN2 turquoise turquoise turquoise turquoise turquoise LRRC15 turquoise turquoise turquoise turquoise turquoise LOX turquoise turquoise turquoise turquoise turquoise MFGE8 turquoise turquoise turquoise turquoise turquoise FAP turquoise turquoise turquoise turquoise turquoise COLEC12 turquoise turquoise turquoise turquoise turquoise FAM20C turquoise turquoise turquoise turquoise turquoise PTPRM turquoise turquoise turquoise turquoise turquoise BCAT1 turquoise turquoise turquoise turquoise turquoise MAF turquoise turquoise turquoise turquoise turquoise COL4A1 turquoise turquoise turquoise turquoise turquoise TUBA1A turquoise turquoise turquoise turquoise turquoise ENTPD1 turquoise turquoise gray turquoise turquoise DFNA5 turquoise turquoise turquoise turquoise turquoise FGFR1 turquoise turquoise turquoise turquoise turquoise S1PR3 turquoise turquoise turquoise turquoise turquoise VGLL3 turquoise turquoise turquoise turquoise turquoise ITGA5 turquoise turquoise turquoise turquoise turquoise PDPN turquoise turquoise turquoise turquoise turquoise GREM1 turquoise turquoise turquoise turquoise turquoise PMP22 turquoise turquoise turquoise turquoise turquoise COL18A1 turquoise turquoise turquoise turquoise turquoise PDGFC turquoise turquoise turquoise turquoise turquoise FN1 turquoise turquoise turquoise turquoise turquoise KCNE4 turquoise turquoise turquoise turquoise turquoise GLIS2 turquoise turquoise turquoise turquoise turquoise EFEMP1 turquoise turquoise turquoise turquoise turquoise ZNF521 turquoise turquoise turquoise turquoise turquoise CERCAM turquoise turquoise turquoise turquoise turquoise NOX4 turquoise turquoise turquoise turquoise turquoise NUAK1 turquoise turquoise turquoise turquoise turquoise COL15A1 turquoise turquoise turquoise turquoise turquoise CRISPLD2 turquoise turquoise turquoise turquoise turquoise LOXL1 turquoise turquoise turquoise turquoise turquoise GFPT2 turquoise turquoise turquoise turquoise turquoise INHBA turquoise turquoise turquoise turquoise turquoise WISP1 turquoise turquoise turquoise turquoise turquoise DPYSL3 turquoise turquoise turquoise turquoise turquoise ZFPM2 turquoise turquoise turquoise turquoise turquoise PPAPDC1A turquoise turquoise turquoise turquoise turquoise MITF turquoise turquoise turquoise turquoise turquoise KIAA1462 turquoise turquoise turquoise turquoise turquoise OLFML1 turquoise turquoise turquoise turquoise turquoise FBLN1 turquoise turquoise turquoise turquoise turquoise PRRX1 turquoise turquoise turquoise turquoise turquoise MFAP2 turquoise turquoise turquoise turquoise turquoise TSHZ3 turquoise turquoise turquoise turquoise turquoise TWIST1 turquoise turquoise turquoise turquoise turquoise POSTN turquoise turquoise turquoise turquoise turquoise MRAS turquoise turquoise turquoise turquoise turquoise IGFBP7 turquoise turquoise turquoise turquoise turquoise TGFB1I1 turquoise turquoise turquoise turquoise turquoise NOTCH3 turquoise turquoise turquoise turquoise turquoise EFS turquoise turquoise turquoise turquoise turquoise BNC2 turquoise turquoise turquoise turquoise turquoise GUCY1A3 turquoise turquoise turquoise turquoise turquoise SFRP2 turquoise turquoise turquoise turquoise turquoise PXDN turquoise turquoise turquoise turquoise turquoise LUM turquoise turquoise turquoise turquoise turquoise COL4A2 turquoise turquoise turquoise turquoise turquoise RCN3 turquoise turquoise turquoise turquoise turquoise LOXL2 turquoise turquoise turquoise turquoise turquoise RFTN1 turquoise turquoise turquoise turquoise turquoise SERPING1 turquoise gray gray turquoise turquoise ASPN turquoise turquoise turquoise turquoise turquoise HOPX turquoise turquoise turquoise turquoise turquoise IGFBP5 turquoise turquoise turquoise turquoise turquoise CDH11 turquoise turquoise turquoise turquoise turquoise VEGFC turquoise turquoise turquoise turquoise turquoise GLT8D2 turquoise turquoise turquoise turquoise turquoise SFRP4 turquoise turquoise turquoise turquoise turquoise LAMA4 turquoise turquoise turquoise turquoise turquoise SDC2 turquoise turquoise turquoise turquoise turquoise CTSK turquoise turquoise turquoise turquoise turquoise NNMT turquoise turquoise turquoise turquoise turquoise COL10A1 turquoise turquoise turquoise turquoise turquoise GAS1 turquoise turquoise turquoise turquoise turquoise DKK3 turquoise turquoise turquoise turquoise turquoise CTHRC1 turquoise turquoise turquoise turquoise turquoise ADAM12 turquoise turquoise turquoise turquoise turquoise SERPINF1 turquoise turquoise turquoise turquoise turquoise TIMP3 turquoise turquoise turquoise turquoise turquoise AXL turquoise turquoise turquoise turquoise turquoise COL6A2 turquoise turquoise turquoise turquoise turquoise C1R turquoise turquoise turquoise turquoise turquoise EMILIN1 turquoise turquoise turquoise turquoise turquoise PTRF turquoise turquoise turquoise turquoise turquoise HTRA1 turquoise turquoise turquoise turquoise turquoise GUCY1B3 turquoise turquoise turquoise turquoise turquoise FIBIN turquoise turquoise turquoise turquoise turquoise LHFP turquoise turquoise turquoise turquoise turquoise MEIS1 turquoise turquoise turquoise turquoise turquoise LAYN turquoise turquoise turquoise turquoise turquoise CALD1 turquoise turquoise turquoise turquoise turquoise FERMT2 turquoise turquoise turquoise turquoise turquoise TNS1 turquoise turquoise turquoise turquoise turquoise MYL9 turquoise turquoise turquoise turquoise turquoise DDR2 turquoise turquoise turquoise turquoise turquoise TAGLN turquoise turquoise turquoise turquoise turquoise JAM3 turquoise turquoise turquoise turquoise turquoise ACTA2 turquoise turquoise turquoise turquoise turquoise MSRB3 turquoise turquoise turquoise turquoise turquoise C1S turquoise turquoise turquoise turquoise turquoise CCDC80 turquoise turquoise turquoise turquoise turquoise MXRA8 turquoise turquoise turquoise turquoise turquoise OSMR turquoise turquoise turquoise turquoise turquoise MXRA5 turquoise turquoise turquoise turquoise turquoise COL6A1 turquoise turquoise turquoise turquoise turquoise ISLR turquoise turquoise turquoise turquoise turquoise LGALS1 turquoise turquoise turquoise turquoise turquoise ADAMTS2 turquoise turquoise turquoise turquoise turquoise ANGPTL2 turquoise turquoise turquoise turquoise turquoise COL1A1 turquoise turquoise turquoise turquoise turquoise OLFML2B turquoise turquoise turquoise turquoise turquoise NTM turquoise turquoise turquoise turquoise turquoise COL11A1 turquoise turquoise turquoise turquoise turquoise FRMD6 turquoise turquoise turquoise turquoise turquoise MMP2 turquoise turquoise turquoise turquoise turquoise TUBB6 turquoise turquoise turquoise turquoise turquoise BGN turquoise turquoise turquoise turquoise turquoise MRC2 turquoise turquoise turquoise turquoise turquoise SPOCK1 turquoise turquoise turquoise turquoise turquoise ADAMTS12 turquoise turquoise turquoise turquoise turquoise PCOLCE turquoise turquoise turquoise turquoise turquoise COL8A1 turquoise turquoise turquoise turquoise turquoise FNDC1 turquoise turquoise turquoise turquoise turquoise SULF1 turquoise turquoise turquoise turquoise turquoise EFEMP2 turquoise turquoise turquoise turquoise turquoise PDGFRB turquoise turquoise turquoise turquoise turquoise AEBP1 turquoise turquoise turquoise turquoise turquoise THBS2 turquoise turquoise turquoise turquoise turquoise THY1 turquoise turquoise turquoise turquoise turquoise VIM turquoise turquoise turquoise turquoise turquoise VCAN turquoise turquoise turquoise turquoise turquoise FSTL1 turquoise turquoise turquoise turquoise turquoise COL12A1 turquoise turquoise turquoise turquoise turquoise ANTXR1 turquoise turquoise turquoise turquoise turquoise COL5A2 turquoise turquoise turquoise turquoise turquoise COL5A1 turquoise turquoise turquoise turquoise turquoise TIMP2 turquoise turquoise turquoise turquoise turquoise COL6A3 turquoise turquoise turquoise turquoise turquoise COL3A1 turquoise turquoise turquoise turquoise turquoise RAB31 turquoise turquoise turquoise turquoise turquoise SPARC turquoise turquoise turquoise turquoise turquoise COL1A2 turquoise turquoise turquoise turquoise turquoise FBN1 turquoise turquoise turquoise turquoise turquoise DCN turquoise turquoise turquoise turquoise turquoise GPC6 turquoise turquoise turquoise turquoise turquoise VASH2 turquoise turquoise gray turquoise turquoise CLDN11 turquoise turquoise turquoise turquoise turquoise SMCR8 black gray black gray C3orf67 turquoise gray turquoise gray NKX2-1 turquoise gray gray gray APBA1 turquoise gray gray gray TRDV3 turquoise gray turquoise gray FOXG1 red gray gray red TF turquoise gray gray turquoise KCNAB1 turquoise turquoise gray gray BAIAP2-AS1 turquoise turquoise gray gray SMPDL3B red gray gray red FIBCD1 turquoise gray turquoise gray HOXA6 turquoise turquoise gray gray AKR1C1 turquoise turquoise gray gray IL11 turquoise gray gray turquoise TMEM184A yellow yellow yellow gray NFASC turquoise gray turquoise gray TNFRSF10C turquoise gray gray gray KCNQ4 turquoise gray turquoise gray TFR2 turquoise gray turquoise gray

REFERENCES

-   -   Andre, T., C. Boni, et al, (2009). “Improved overall survival         with oxaliplatin, fluorouracil, and leucovorin as adjuvant         treatment in stage II or III colon cancer in the MOSAIC trial. ”         J Clin Oncol 27(19): 3109-3116.     -   Cersosimo, R. J. (2005) “Oxaliplatin-associated neuropathy: a         review.” Ann Pharmacother 39(1): 128-135.     -   De Sousa, E. M. F. X. Wang, et al. (2013). “Poor-prognosis colon         cancer is defined by a molecularly distinct subtype and develops         from serrated precursor lesions.” Nat Med 19(5): 614-618.     -   Isella, C., A. Terrasi, et al., (2015), “Stromal contribution to         the colorectal cancer transcriptome.” Nat Genet 47(4): 312-319.     -   Kuebler, J. P., H. S. Wieand, et al (2007). “Oxaliplatin         combined with weekly bolus fluorouracil and leucovorin as         surgical adjuvant chemotherapy for stage II and III colon         cancer: results from NSABP C-07. ” J Clin Oncol 25(16):         2198-2204.     -   Marisa, L., A. de Reynies, et al. (2013). “Gene expression         classification of colon cancer into molecular subtypes:         characterization, validation, and prognostic value.” PLoS Med         10(5): e1001453.     -   Sadanandam, A., C. A. Lyssiotis, et al. (2013): “A colorectal         cancer classification system that associates cellular phenotype         and responses to therapy.” Nat Med 19(5): 619-625.     -   Tournigand, C., T. Andre. et al. (2012). “Adjuvant therapy with         fluorouracil and oxaliplatin in stage II and elderly patients         (between ages 70 and 75 years) with colon cancer subgroup         analyses of the Multicenter International Study of Oxaliplatin,         Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon         Cancer trial.” J Clinc Oncol 30(27): 3353-3360. 

1. A method for treating colon cancer in a patient in need thereof said method comprising: obtaining a tumor tissue sample from said patient; determining a gene expression signature of said sample; identifying a tumor tissue subtype or sub-subtype from said gene expression signature; and administering oxaliplatin when the identified minor tissue subtype or sub-subtype is an oxidiplatin responsive subtype or sub-subtype.
 2. The method of claim 1, the step of determining a gene expression signature comprises contacting a genetic sample from the tumor tissue sample with a plurality of specific genetic sequence binding targets and measuring the amount of genetic material expressed by the tumor tissue for a panel of selected genes, wherein the panel of genes are selected from those listed in Table
 2. 3. The method of claim 2, wherein the genetic sample comprises cDNA or RNA either in a purified form or as a tissue lysate.
 4. The method of claim 1, wherein selecting genes from Table 5 comprises Weighted Gene Correlation Network Analysis (WGCNA), to identify members of oxaliplatin responsive gene modules.
 5. The method of claim 1, wherein the identified tumor tissue subtype is a subtype or sub-subtype of the enterocyte tissue type.
 6. The method of claim 1, wherein oxaliplatin is administered in combination with 5-fluorouracil plus leucovorin (FULV).
 7. The method of claim 1, wherein the patient is a stage II colon cancer patient.
 8. The method of claim 1, wherein the cancer tumor sample is subtype TA or a sub-subtype of TA.
 9. A method for treating colon cancer in a patient in need thereof said method comprising: obtaining, a tumor tissue sample from said patient; isolating, RNA from the tumor tissue sample; contacting the RNA sample with a plurality of sequence specific probes effective to determine levels of expression of a panel of selected genes in the tumor sample to obtain a gene signature; identifying a colon cancer subtype or sub-subtype tumor subtype based on the gene signature; and administering oxaliplatin or causing oxaliplatin to be administered to said patient when the cancer subtype or sub-subtype is an oxaliplatin responsive subtype or sub-subtype.
 10. The method of claim 9, wherein the panel of selected genes are selected from the genes listed in Table
 5. 11. The method of claim 9, wherein the oxoliplatin is administered in combination with 5-fluorouracil plus leocovorin (FULV).
 12. The method of claim 9, wherein the patient is a stage II colon cancer patient.
 13. The method of claim 9, wherein the cancer tumor sample is subtype enterocyte or a sub-subtype of enterocyte.
 14. The method of claim 10, wherein the cancer tumor sample is subtype TA or a sub-subtype of stem-like. 